Angiotensin in the kidney: A key to understanding hypertension?

被引：4

作者：

Muscha Steckelings, Ulrike

Rettig, Rainer

Unger, Thomas ^{[1
]}

机构：

[1] Univ Med Berlin, Charite, Inst Pharmacol, Cardiovasc Res Ctr, D-10115 Berlin, Germany

[2] Ernst Moritz Arndt Univ Greifswald, Inst Physiol, D-17495 Karlsburg, Germany

来源：

CELL METABOLISM | 2007年 / 5卷 / 01期

关键词：

D O I：

10.1016/j.cmet.2006.12.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A crosstransplantation study between genetically matched angiotensin AT1 receptor knockout and wild-type mice revealed that renal AT1 receptors are required for the development of angiotensin II-induced hypertension (Crowley et al., 2006). However, in this experimental setting, hypertension-related left ventricular hypertrophy seemed to depend on blood pressure elevation rather than on the expression of AT1 receptors in the heart.

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页码：7 / 8

页数：2

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