Cannabinoids in the treatment of cancer

被引：91
作者：
Alexander, Amy [1 ]
Smith, Paul F. [1 ]
Rosengren, Rhonda J. [1 ]
机构：
[1] Univ Otago, Dept Pharmacol & Toxicol, Dunedin, New Zealand
来源：
CANCER LETTERS | 2009年 / 285卷 / 01期
关键词：
Cannabinoids; JWH-133; CB1; CB2; MAPK; ACTIVATED PROTEIN-KINASE; NECROSIS-FACTOR-ALPHA; SELECTIVE ANTAGONIST; RECEPTOR; STIMULATION; INVOLVEMENT; GROWTH; CB1; CELLS; PROLIFERATION;
D O I：
10.1016/j.canlet.2009.04.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cannabinoids, the active components of the hemp plant Cannabis sativa, along with their endogenous counterparts and synthetic derivatives, have elicited anti-cancer effects in many different in vitro and in vivo models of cancer. While the various cannabinoids have been examined in a variety of cancer models, recent studies have focused on the role of cannabinoid receptor agonists (both CB1 and CB2) in the treatment of estrogen receptor-negative breast cancer. This review will summarize the anti-cancer properties of the cannabinoids, discuss their potential mechanisms of action, as well as explore controversies surrounding the results. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：6 / 12
页数：7
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