Dependence of rat spot14 promoter activity on NF-Y binding to the inverted CCAAT-element at-100

被引：2

作者：

Roder, K ^{[1
]}

Wolf, SS ^{[1
]}

Schweizer, M ^{[1
]}

机构：

[1] Heriot Watt Univ, Dept Biol Sci, Edinburgh EH14 4AS, Midlothian, Scotland

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2000年 / 64卷 / 04期

关键词：

spot14; promoter; fatty acid synthase; NF-Y; inverted CCAAT-element;

D O I：

10.1271/bbb.64.848

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Electrophoretic mobility Shift assay (EMSA) and in vitro transcription/translation show that NF-Y binds to the inverted CCAAT-element in the promoter of the rodent spot14 gene. The NF-Y-binding sequence has been shown to be responsible for basal activity in H4IIE. Given the similar role found for the inverted CCAAT-element in the promoter of the FAS gene, NF-Y may have an important function in the control of lipogenesis.

引用

页码：848 / 851

页数：4