I2 Promoted Synthesis of 2-Aminothiadiazoles Employing KSCN as a Sulfur Source Under Metal-Free Conditions

被引：11

作者：

Zhu, Fuyuan ^{[1
]}

Yan, Zhaohua ^{[1
]}

Ai, Chengmei ^{[1
]}

Wang, Yanmei ^{[1
]}

Lin, Sen ^{[1
]}

机构：

[1] Nanchang Univ, Coll Chem, 999 Xuefu Dadao, Nanchang 330031, Jiangxi, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 38期

基金：

中国国家自然科学基金;

关键词：

Three-component reaction; Iodine-promoted reaction; Metal-free condition; 2-Aminothiadiazole; Potassium thiocyanate; ONE-POT SYNTHESIS; HURD-MORI-REACTION; 1,3,4-THIADIAZOLE DERIVATIVES; MOLECULAR-IODINE; DEPRESSANT ACTIVITY; MEDIATED SYNTHESIS; N-TOSYLHYDRAZONES; C-N; BOND; 2-AMINO-1,3,4-THIADIAZOLES;

D O I：

10.1002/ejoc.201901250

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new three-component strategy from aldehyde, p-toluenesulfonyl hydrazide and potassium thiocyanate for the synthesis of 2-aminothiadiazoles promoted by I-2 under metal-free conditions has been described. Potassium thiocyanate was used as an odorless and low-toxicity sulfur source. A wide range of aromatic aldehydes can smoothly undergo the three-component cyclization reaction under the optimized conditions to give the corresponding products in moderate to good yields.

引用

页码：6561 / 6565

页数：5

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