Synthesis of non-proteinogenic phenylalanine derivatives by rhodium-catalyzed [2+2+2] cycloaddition reactions

被引：16
作者：
Garcia, Lidia [1 ]
Pla-Quintana, Anna [1 ]
Roglans, Anna [1 ]
机构：
[1] Univ Girona, Dept Chem, Girona 17071, Spain
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 23期
关键词：
ALPHA-AMINO-ACIDS; ENANTIOSELECTIVE SYNTHESIS; TIC DERIVATIVES; 1,6-DIYNES; PEPTIDES; DESIGN; CYCLOISOMERIZATIONS; CYCLOTRIMERIZATION; CONSTRUCTION; SCAFFOLDS;
D O I：
10.1039/b910961g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Non-proteinogenic phenylalanine derivatives were efficiently prepared by Rh(I)-catalyzed [2+2+2] cycloaddition reactions between enantiopure and racemic propargylglycine amino acids, with different protective groups, and diynes. Diverse substituents, including tags such as dansyl or dabsyl, were introduced onto the aromatic ring of the amino acid derivatives by selecting the most appropriate diyne reacting partners.
引用
收藏
页码：5020 / 5027
页数：8
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