KSHV-encoded viral interferon regulatory factor 4 (vIRF4) interacts with IRF7 and inhibits interferon alpha production

被引：36

作者：

Hwang, Sung-Woo ^{[1
]}

Kim, Donglk ^{[1
]}

Jung, Jae U. ^{[2
]}

Lee, Hye-Ra ^{[1
]}

机构：

[1] Korea Univ, Coll Sci & Technol, Dept Biotechnol & Bioinformat, Sejong Campus, Sejong 30019, South Korea

[2] Univ Southern Calif, Keck Sch Med, Zikha Neurogen Inst, Dept Mol Microbiol & Immunol, 1501 San Pablo St, Los Angeles, CA 90089 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2017年 / 486卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

KSHV; vIRF4; IRF7; Innate immunity; IFN-alpha; SARCOMA-ASSOCIATED HERPESVIRUS; ANTIVIRAL RESPONSE; EVASION STRATEGIES; ACTIVATION; INDUCTION; PROTEIN; GENES; HHV-8;

D O I：

10.1016/j.bbrc.2017.03.101

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Before an infection can be completely established, the host immediately turns on the innate immune system through activating the interferon (IFN)-mediated antiviral pathway. Kaposi's sarcoma-associated herpesvirus (KSHV) utilizes a unique antagonistic mechanism of type I IFN-mediated host antiviral immunity by incorporating four viral interferon regulatory factors (vIRF1-4). Herein, we characterized novel immune evasion strategies of vIRF4 to inhibit the IRF7-mediated IFN-alpha production. KSHV vIRF4 specifically interacts with IRF7, resulting in inhibition of IRF7 dimerization and ultimately suppresses IRF7-mediated activation of type I IFN. These results suggest that each of the KSHV vIRFs, including vIRF4, subvert IFN-mediated anti-viral response via different mechanisms. Therefore, it is indicated that KSHV vIRFs are indeed a crucial immunomodulatory component of their life cycles. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：700 / 705

页数：6

共 22 条

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