Cerebral aspergillosis diagnosed by detection of Aspergillus flavus-specific DNA, galactomannan and (1→3)-β-D-glucan in clinical specimens

被引：24

作者：

Khan, Zia U. ^{[1
]}

Ahmad, Suhail

Mokaddas, Eiman

Said, Tarek

Nair, M. P.

Halim, M. A.

Nampoory, M. R.

McGinnis, M. R.

机构：

[1] Kuwait Univ, Fac Med, Dept Microbiol, Safat 13110, Kuwait

[2] Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 2007年 / 56卷 / 01期

关键词：

D O I：

10.1099/jmm.0.46549-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A case of cerebral aspergillosis was diagnosed by the detection of Aspergillus flavus-specific DNA in brain biopsy and serum specimens. The diagnosis was also Supported by detection of elevated levels of galactomannan and (1 -> 3)-beta-D-glucan in serum specimens. Despite the presence of dichotomously branched septate hyphae in brain biopsy, the culture remained negative. The inability to isolate the organism in culture suggested that combined therapy of AmBisome and caspofungin was fungicidal for the fungus in the brain abscess.

引用

页码：129 / 132

页数：4

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