An isochromosome 6p in a primary meningeal malignant melanoma

被引：13
作者：
Baudrier-Régnier, A
Bodenant, C
Proust, F
Delangre, T
Hemet, J
Laquerrière, A
机构：
[1] Univ Rouen, Hosp Charles Nicolle, Lab Pathol Anat & Cytol, Rouen, France
[2] Univ Rouen, Hosp Charles Nicolle, Dept Neurosurg, Rouen, France
[3] Univ Rouen, Hosp Charles Nicolle, Dept Neurol, Rouen, France
来源：
CANCER GENETICS AND CYTOGENETICS | 2000年 / 119卷 / 01期
关键词：
D O I：
10.1016/S0165-4608(99)00215-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The rearrangement of chromosome 6, particularly the deletion of 6q, has been observed in human malignant melanoma with or without brain metastases. The isochromosome 6p has also been described. In this study, we report the cytogenetic analysis of a primary malignant melanoma of the central nervous system. Its dominating karyotype was 47,XX, +i(6)(p10). Fluorescence in situ hybridization (FISH), using a 6p chromosome ann probe, confirmed the structure of the isochromosome, To our knowledge, this is the first report of this type of chromosomal aberration in an uncommon neoplasm of leptomeningeal melanocytic origin. (C) 2000 Elsevier Science Inc. All rights reserved.
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页码：80 / 82
页数：3
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