Association of the N-acetyltransferase I gene (NATI) with mild and severe substance abuse

被引：5

作者：

Comings, DE

Muhleman, D

Wu, SJ

MacMurray, J

机构：

[1] City Hope Natl Med Ctr, Dept Med Genet, Duarte, CA 91010 USA

[2] Loma Linda Univ, Sch Med, Dept Psychiat, Loma Linda, CA USA

来源：

NEUROREPORT | 2000年 / 11卷 / 06期

关键词：

endorphins; opioids; substance abuse;

D O I：

10.1097/00001756-200004270-00017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We observed a significant increase in the number subjects carrying the NAT1*10 allele of the N-acetyl transferase 1 (NAT1) gene in controls with a MAST-R score of greater than or equal to 4 and in subjects with drug and/or alcohol dependence (p=0.003), compared with controls with a MAST-R <4. These results suggest that alterations in the acetylation of one or more CNS compounds may be related to both mild and severe substance abuse. NeuroReport 11:1227-1230 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：1227 / 1230

页数：4

共 22 条

[1]

BELL DA, 1995, CANCER RES, V55, P3537

[2]

BELL DA, 1995, CANCER RES, V55, P5226

[3] HUMAN ARYLAMINE N-ACETYLTRANSFERASE GENES - ISOLATION, CHROMOSOMAL LOCALIZATION, AND FUNCTIONAL EXPRESSION [J].