Dynamic expression of glial cell line-derived neurotrophic factor after cerebral ischemia

被引：59

作者：

Wei, GW ^{[1
]}

Wu, GC ^{[1
]}

Cao, XD ^{[1
]}

机构：

[1] Shanghai Med Univ, Dept Neurobiol, Natl Lab Med Neurobiol, Shanghai 200032, Peoples R China

来源：

NEUROREPORT | 2000年 / 11卷 / 06期

关键词：

cerebral cortex; cerebral ischemia; glial cell line-derived neurotrophic factor (GDNF); striatum;

D O I：

10.1097/00001756-200004270-00007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of this study was to understand the possible involvement of glial cell line-derived neurotrophic factor (GDNF) in rat brain ischemic injury by examining the expression and the cellular location of GDNF with molecular biological and morphological techniques. Expression of GDNF mRNA and protein was first increased as early as 2 h after ischemia-reperfusion in peri-infarct cerebral cortex and striatum; it then declined, and showed a second increase at 72 h. Double staining confirmed that the earlier peak of GDNF expression was of neuronal origin and the later peak of glial origin. Considering the neurotrophic characteristics of GDNF, our findings suggest that elevated endogenous GDNF expression may have important roles in protection of ischemic injured neuronal cells. NeuroReport 11:1177-1183 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：1177 / 1183

页数：7

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