Effects of a Diet Higher in Carbohydrate/Lower in Fat Versus Lower in Carbohydrate/Higher in Monounsaturated Fat on Postmeal Triglyceride Concentrations and Other Cardiovascular Risk Factors in Type 1 Diabetes

被引：42

作者：

Strychar, Irene ^{[1
,2
,3
,4
]}

Cohn, Jeffrey S. ^{[5
]}

Renier, Genevieve ^{[1
,2
,3
,4
]}

Rivard, Michele ^{[6
]}

Aris-Jilwan, Nahla ^{[3
]}

Beauregard, Hugues ^{[3
]}

Meltzer, Sara ^{[7
]}

Belanger, Andre ^{[8
]}

Dumas, Richard ^{[8
]}

Ishac, Alain ^{[1
]}

Radwan, Farouk ^{[9
]}

Yale, Jean-Francois ^{[7
]}

机构：

[1] Univ Montreal, Res Ctr, Ctr Hosp, Montreal, PQ, Canada

[2] Montreal Diabet Res Ctr CRCHUM, Montreal, PQ, Canada

[3] Univ Montreal, Notre Dame Hosp, Serv Endocrinol, Ctr Hosp, Montreal, PQ H3C 3J7, Canada

[4] Univ Montreal, Dept Nutr, Fac Med, Montreal, PQ H3C 3J7, Canada

[5] Heart Res Inst, Sydney, NSW, Australia

[6] Univ Montreal, Dept Social & Prevent Med, Montreal, PQ, Canada

[7] McGill Univ, Royal Victoria Hosp, Nutr & Food Sci Ctr, Ctr Hlth, Montreal, PQ H3A 1A1, Canada

[8] Laval Clin, Res Ctr, Montreal, PQ, Canada

[9] Notre Dame Hosp CHUM, Dept Biochem, Montreal, PQ, Canada

来源：

DIABETES CARE | 2009年 / 32卷 / 09期

基金：

加拿大健康研究院;

关键词：

D O I：

10.2337/dc08-2322

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE - To compare the effects of a eucaloric diet higher in carbohydrate/lower in fat versus lower in carbohydrate/higher in monounsaturated fat on postmeal triglyceride (TG) concentrations and other cardiovascular disease risk factors in nonobese subjects with type 1 diabetes and in good glycemic control. RESEARCH DESIGN AND METHODS - In a parallel group design study, 30 subjects were randomly assigned and completed one of the two eucaloric diets. Assessments included: BMI, blood pressure, A1C, plasma lipids, and markers of oxidation, thrombosis, and inflammation. At 6 months, subjects were hospitalized for 24 h to measure plasma TG excursions. RESULTS - There were no significant differences between groups other than decreased plasminogen activator inhibitor 1 (PAI-1) levels and weight gain in the lower-carbohyd rate/higher-monounsaturated fat group. During the 24-h testing, the lower-carbohydrate/higher-monounsaturated fat group had a lower plasma TG profile. CONCLUSIONS - A diet lower in carbohydrate/higher in monounsaturated fat could offer an appropriate choice for nonobese type 1 diabetic individuals with good metabolic and weight control.

引用

页码：1597 / 1599

页数：3

共 16 条

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