Concise Syntheses of Violaceoids A and C

被引：4
|
作者：
Narita, Koichi [1 ]
Kimura, Ryuhei [1 ]
Satoh, Hiroka [1 ]
Watanabe, Kazuhiro [1 ]
Yoshimura, Yuichi [1 ,2 ]
机构：
[1] Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Lab Synthet & Med Chem, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan
[2] Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Lab Organ & Pharmaceut Chem, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2021年 / 69卷 / 02期
基金：
日本学术振兴会;
关键词：
violaceoid; alkylated hydroquinone; protecting-group-free synthesis; total synthesis; EFFICIENT SYNTHESIS; ALDEHYDES; PHENOLS;
D O I：
10.1248/cpb.c20-00816
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The concise syntheses of two alkylated hydroquinone natural products, violaceoids A and C, were accomplished by a protecting-group-free method employing the commercially available 2,5-dihydroxybenzaldehyde as the starting material. The key strategy of the syntheses is the utilization of alkenylboronic acid as both the coupling and temporary protective reagents to efficiently introduce the requisite alkenyl side chain of violaceoid A. Moreover, the synthesis of violaceoid C is reported here for the first time.
引用
收藏
页码：232 / 235
页数：4
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