Receptors for myelin inhibitors: Structures and therapeutic opportunities

被引:53
作者
Cao, Zixuan [2 ]
Gao, Ying [2 ]
Deng, Kangwen [2 ]
Williams, Gareth [1 ]
Doherty, Patrick [1 ]
Walsh, Frank S. [1 ]
机构
[1] Kings Coll London, Wolfson Ctr Age Related Dis, London SE1 9RT, England
[2] Wyeth Ayerst Res, Neurosci Discovery, Princeton, NJ 08543 USA
关键词
CNS regeneration; Nogo-A; MAG; Omgp; NgR1; Antibodies; Myelin; Gangliosides; GT1b; Lingo-1; p75; RhoA; SPINAL-CORD-INJURY; CENTRAL-NERVOUS-SYSTEM; CHONDROITIN SULFATE PROTEOGLYCANS; NEURITE GROWTH-INHIBITORS; IMMUNOGLOBULIN-LIKE RECEPTORS; HUMAN NEUROBLASTOMA-CELLS; RETINAL GANGLION-CELLS; CNS WHITE MATTER; CLASS-I MHC; AXONAL REGENERATION;
D O I
10.1016/j.mcn.2009.07.008
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Many studies have indicated that the inability of adult mammalian central nervous system (CNS) to regenerate after injury is partly due to the existence of growth-inhibitory molecules associated with CNS myelin. Studies over the years have led to the identification of multiple myelin-associated inhibitors, among which Nogo, myelin-associated glycoprotein (MAC) and oligodendrocyte-myelin glycoprotein (Omgp) represent potentially major contributors to CNS axon regeneration failure. Here we review in vitro and in vivo investigations into these inhibitory ligands and their functional mechanisms, focusing particularly on the neuronal receptors that mediate the inhibitory signals from these myelin molecules. A better understanding of the receptors for myelin-associated inhibitors could provide opportunities to decipher the mechanism of restriction in CNS regeneration, and lead to the development of potential therapeutic targets in neurodegenerative diseases and neurological injury. We will discuss the Structures of the receptors and therapeutic opportunities that might arise based on this information. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:1 / 14
页数:14
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