Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

被引：16
作者：
Yamanouchi, S
Shimazoe, T
Nagata, S
Moriya, T
Maetani, M
Shibata, S
Watanabe, S
Miyasaka, K
Kono, A
Funakoshi, A
机构：
[1] KYUSHU UNIV 62,FAC PHARMACEUT SCI,DEPT PHARMACOL,FUKUOKA 81282,JAPAN
[2] WASEDA UNIV,SCH HUMAN SCI,DEPT PHARMACOL,TOKOROZAWA,SAITAMA 359,JAPAN
[3] TOKYO METROPOLITAN INST GERONTOL,DEPT CLIN PHYSIOL,TOKYO 173,JAPAN
[4] KYUSHU NATL CANC CTR,FUKUOKA 815,JAPAN
来源：
NEUROSCIENCE LETTERS | 1997年 / 227卷 / 02期
关键词：
diabetes; circadian rhythm; suprachiasmatic nucleus; streptozotocin; Otsuka Long-Evans Tokushima fatty rats; Fos;
D O I：
10.1016/S0304-3940(97)00324-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ-induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN). (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码：103 / 106
页数：4
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