Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

被引：16

作者：

Yamanouchi, S

Shimazoe, T

Nagata, S

Moriya, T

Maetani, M

Shibata, S

Watanabe, S

Miyasaka, K

Kono, A

Funakoshi, A

机构：

[1] KYUSHU UNIV 62,FAC PHARMACEUT SCI,DEPT PHARMACOL,FUKUOKA 81282,JAPAN

[2] WASEDA UNIV,SCH HUMAN SCI,DEPT PHARMACOL,TOKOROZAWA,SAITAMA 359,JAPAN

[3] TOKYO METROPOLITAN INST GERONTOL,DEPT CLIN PHYSIOL,TOKYO 173,JAPAN

[4] KYUSHU NATL CANC CTR,FUKUOKA 815,JAPAN

来源：

NEUROSCIENCE LETTERS | 1997年 / 227卷 / 02期

关键词：

diabetes; circadian rhythm; suprachiasmatic nucleus; streptozotocin; Otsuka Long-Evans Tokushima fatty rats; Fos;

D O I：

10.1016/S0304-3940(97)00324-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ-induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN). (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：103 / 106

页数：4

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