Thrombosis and antithrombotic agents in peripheral arterial disease

Aspirin remains the most useful antithrombotic agent in peripheral arterial disease. In intermittent claudication, there is no indication for oral anticoagulant except in the presence of emboligen cardiopathy (atrial fibrillation, valvular prosthesis). In critical leg ischemia, there is no proof of benefit for anticoagulation. In the prevention of distal bypass of the legs, the same efficacy is observed for aspirin and oral anticoagulant, but in both treatment occlusion remains frequent, 25% of patients after two years of follow-up.