PIM-1 kinase: a potential biomarker of triple-negative breast cancer

被引：32

作者：

Chen, Jieying ^{[1
]}

Tang, Guangyu ^{[1
]}

机构：

[1] Tongji Univ, Sch Med, Dept Radiol, Shanghai Peoples Hosp 10, 301 Middle Yanchang Rd, Shanghai 200072, Peoples R China

来源：

ONCOTARGETS AND THERAPY | 2019年 / 12卷

基金：

中国国家自然科学基金;

关键词：

triple-negative breast cancer; biomarker; PIM-1; CELL-CYCLE PROGRESSION; C-MYC; PROTOONCOGENE PIM-1; GENE-PRODUCT; PROTEIN; EXPRESSION; PHOSPHORYLATES; PROMOTES; TRANSCRIPTION; TARGET;

D O I：

10.2147/OTT.S212752

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Triple-negative breast cancer is associated with a poor prognosis, and effective biomarkers for targeted diagnosis and treatment are lacking. The tumorigenicity of the provirus integration site for Moloney murine leukemia virus 1 (PIM-1) gene has been studied for many years. However, its significance in breast cancer remains unclear. In this review we briefly summarized the physiological characteristics and regulation of PIM-1 kinase, and subsequently focused on the role of PIM-1 in tumors, especially breast cancer. Oncogene PIM-1 was found to be upregulated in breast cancer, especially in triple-negative breast cancer. Moreover, it is involved in tumorigenesis and the development of drug resistance, and linked to poor prognosis. A highly selective probe targeting PIM-1 for imaging has emerged, suggesting that PIM-1 may be a potential biomarker for the accurate diagnosis and targeted therapy of triple-negative breast cancer.

引用

收藏

页码：6267 / 6273

页数：7

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