Biodiesel has been renowned as potential and alternative fuel for years. In order to improve the quality of the conventional fossil fuels, biodiesel, and air pollution from combustion, additives are essential to exploit. In this study, the effects of silicon dioxide nanoparticle additives when added to the Mahua methyl ester (MME) blend on CRDI diesel engine are investigated. The blends used for the experimental study are denoted as given (MME20 + SIO40, MME20 + SIO80, and MME20 + SIO120). The experimental results reveal that the brake thermal efficiency of SiO2 blended MME shows a slight increase, whereas BSFC (Brake specific fuel consumption) shows a decreasing trend compared with other blends previously tested. The smoke emission, HC (unburnt hydrocarbons), and CO (carbon monoxide) reduce when compared with conventional diesel. Out of all the blends, the silicon dioxide blended with MME has a higher value of NOx (nitrogen oxide) emissions. The engine's overall performance showed a considerable improvement when silicon dioxide was blended with biodiesel, and this blend eventually reduced the toxic emissions from the engine.