Biclonal chronic lymphocytic leukemia

被引：23

作者：

Hsi, ED ^{[1
]}

Hoeltge, G ^{[1
]}

Tubbs, RR ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Dept Clin Pathol, L-11,9500 Euclid Ave, Cleveland, OH 44195 USA

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2000年 / 113卷 / 06期

关键词：

chronic lymphocytic leukemia; biclonal; flow cytometry; gene rearrangement; cell sorting;

D O I：

10.1309/V8AN-A2XP-7TDV-HR0T

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Chronic lymphocytic leukemia (CLL) is well characterized clinically and immunophenotypically. Demonstration of a monotypic CD19+, CD5+ B-cell population is central to the diagnosis. We report 2 cases of biclonal CLL. Two elderly man were encountered with an absolute lymphocytosis consisting of the typical CD5+, CD19+, CD23+ B-cell population seen in CLL; however, immunoglobulin light chain restriction by flow cytometry was not apparent as B cells expressed kappa or lambda light chains without a clear monotypic population. Molecular genetic analysis of flow cytometry-sorted cells (kappa and lambda populations) revealed in both cases 2 monoclonal B-cell populations. The characterization of these cases and a review of the issues surrounding biclonal CLL are presented.

引用

页码：798 / 804

页数：7

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