Protective Role of Complement C5a in an Experimental Model of Staphylococcus aureus Bacteremia

被引：30
|
作者：
von Koeckritz-Blickwede, Maren [1 ]
Konrad, Stephanie [2 ]
Foster, Simon [3 ]
Gessner, J. Engelbert [2 ]
Medina, Eva [1 ]
机构：
[1] Helmholtz Ctr Infect Res, Infect Immunol Res Grp, DE-38124 Braunschweig, Germany
[2] Hannover Med Sch, Clin Immunol & Rheumatol, Hannover, Germany
[3] Univ Sheffield, Dept Mol Biol & Biotechnol, Western Bank, Sheffield S10 2TN, S Yorkshire, England
来源：
JOURNAL OF INNATE IMMUNITY | 2010年 / 2卷 / 01期
关键词：
Bacteremia; Complement C5a; Infection; susceptibility; Staphylococcus aureus; 5TH COMPONENT; DEFICIENCY; SEPSIS; EPIDEMIOLOGY; INFECTION; DEFECT; MICE;
D O I：
10.1159/000247157
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The complement system is a key component of the innate immune response. Here, we have examined the role of complement anaphylatoxin C5a in an experimental model of Staphylococcus aureus bacteremia. Our data provide compelling evidence for a protective role of C5a during staphylococcal bloodstream infection. Copyright (C) 2009 S. Karger AG, Basel
引用
收藏
页码：87 / 92
页数：6
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