Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells

被引：37

作者：

Perry, Sara E.

Robinson, Philip

Melcher, Alan

Quirke, Philip

Buehring, Hans-Joerg

Cook, Graham P.

Blair, G. Eric

机构：

[1] Univ Leeds, Fac Biol Sci, Inst Mol & Cellular Biol, Leeds LS2 9JT, W Yorkshire, England

[2] St James Univ Hosp, Leeds Inst Mol Med, Leeds LS9 7TF, W Yorkshire, England

[3] Univ Tubingen, Dept Internal Med 2, Div Hematol Immunol & Oncol, D-72074 Tubingen, Germany

来源：

FEBS LETTERS | 2007年 / 581卷 / 06期

关键词：

CUB domain; CUB domain containing protein 1; epithelial cell adhesion molecule; carcinoembryonic antigen; colorectal cancer;

D O I：

10.1016/j.febslet.2007.02.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of CUB domain containing protein I (CDCPI) is upregulated in carcinoma cells. We quantitated CDCPI gene expression in matched normal colon and tumour tissue and compared the level of expression to other genes upregulated in colorectal tumourigenesis. Furthermore, we show that the CDCPI gene generates two transcripts which are co-expressed in normal and matched tumour tissue as well as in the majority of cell lines analysed. However, intracellular localisation studies revealed that only one of these transcripts encodes a protein that is localised to the cell surface. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1137 / 1142

页数：6

共 21 条

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