Decoupling of reaction time-related default mode network activity with cognitive demand

被引:10
作者
Barber, Anita D. [1 ]
Caffo, Brian S. [2 ]
Pekar, James J. [3 ,4 ]
Mostofsky, Stewart H. [3 ,4 ]
机构
[1] Feinstein Inst Med Res, 350 Community Dr, Manhasset, NY 11030 USA
[2] Johns Hopkins Sch Publ Hlth, 615 North Wolfe St, Baltimore, MD 21205 USA
[3] Kennedy Krieger Inst, 707 N Broadway, Baltimore, MD 21205 USA
[4] Johns Hopkins Sch Med, 733 N Broadway, Baltimore, MD 21205 USA
关键词
Default mode network; Reaction times; Attention; Anti-correlation; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; MEDIAL FRONTAL-CORTEX; PSYCHOPHYSIOLOGICAL INTERACTIONS; FUNCTIONAL CONNECTIVITY; HUMAN BRAIN; TASK; VARIABILITY; ORGANIZATION; ERROR; FMRI;
D O I
10.1007/s11682-016-9543-4
中图分类号
R445 [影像诊断学];
学科分类号
100207 ;
摘要
Reaction Time (RT) is associated with increased amplitude of the Blood Oxygen-Level Dependent (BOLD) response in task positive regions. Few studies have focused on whether opposing RT-related suppression of task activity also occurs. The current study used two Go/No-go tasks with different cognitive demands to examine regions that showed greater BOLD suppression for longer RT trials. These RT-related suppression effects occurred within the DMN and were task-specific, localizing to separate regions for the two tasks. In the task requiring working memory, RT-related de-coupling of the DMN occurred. This was reflected by opposing RT-BOLD effects for different DMN regions, as well as by reduced positive RT-related Psycho-Physiological Interaction (PPI) connectivity within the DMN and a lack of negative RT-related PPI connectivity between DMN and task positive regions. The results suggest that RT-related DMN suppression is task-specific. RT-related de-coupling of the DMN with more complex task demands may contribute to lapses of attention and performance decrements that occur during cognitively-demanding tasks.
引用
收藏
页码:666 / 676
页数:11
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