Decoupling of reaction time-related default mode network activity with cognitive demand

被引：9

作者：

Barber, Anita D. ^{[1
]}

Caffo, Brian S. ^{[2
]}

Pekar, James J. ^{[3
,4
]}

Mostofsky, Stewart H. ^{[3
,4
]}

机构：

[1] Feinstein Inst Med Res, 350 Community Dr, Manhasset, NY 11030 USA

[2] Johns Hopkins Sch Publ Hlth, 615 North Wolfe St, Baltimore, MD 21205 USA

[3] Kennedy Krieger Inst, 707 N Broadway, Baltimore, MD 21205 USA

[4] Johns Hopkins Sch Med, 733 N Broadway, Baltimore, MD 21205 USA

来源：

BRAIN IMAGING AND BEHAVIOR | 2017年 / 11卷 / 03期

关键词：

Default mode network; Reaction times; Attention; Anti-correlation; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; MEDIAL FRONTAL-CORTEX; PSYCHOPHYSIOLOGICAL INTERACTIONS; FUNCTIONAL CONNECTIVITY; HUMAN BRAIN; TASK; VARIABILITY; ORGANIZATION; ERROR; FMRI;

D O I：

10.1007/s11682-016-9543-4

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

Reaction Time (RT) is associated with increased amplitude of the Blood Oxygen-Level Dependent (BOLD) response in task positive regions. Few studies have focused on whether opposing RT-related suppression of task activity also occurs. The current study used two Go/No-go tasks with different cognitive demands to examine regions that showed greater BOLD suppression for longer RT trials. These RT-related suppression effects occurred within the DMN and were task-specific, localizing to separate regions for the two tasks. In the task requiring working memory, RT-related de-coupling of the DMN occurred. This was reflected by opposing RT-BOLD effects for different DMN regions, as well as by reduced positive RT-related Psycho-Physiological Interaction (PPI) connectivity within the DMN and a lack of negative RT-related PPI connectivity between DMN and task positive regions. The results suggest that RT-related DMN suppression is task-specific. RT-related de-coupling of the DMN with more complex task demands may contribute to lapses of attention and performance decrements that occur during cognitively-demanding tasks.

引用

页码：666 / 676

页数：11

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