Typhus and Other Rickettsioses Emerging Infections in Germany

被引:67
作者
Dobler, Gerhard [1 ]
Woelfel, Roman [1 ]
机构
[1] Inst Mikrobiol Bundeswehr, D-80937 Munich, Germany
来源
DEUTSCHES ARZTEBLATT INTERNATIONAL | 2009年 / 106卷 / 20期
关键词
rickettsiosis; molecular biology; parasitosis; tick bite; head lice; MEDITERRANEAN SPOTTED-FEVER; TICK-BORNE RICKETTSIOSES; EPIDEMIC TYPHUS; MONACENSIS; PREVALENCE; SPECIMENS; DIAGNOSIS; TRAVELERS; DISEASES; SPP;
D O I
10.3238/arztebl.2009.0348
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Rickettsioses are diseases caused by rickettsiae, obligate intracellular bacteria that are transmitted by arthropods to humans. They cause various types of spotted fever and typhus. Methods: A review of the literature is presented along with the authors' own findings. Results: Six indigenous species of rickettsiae have been found in Germany to date, five of which have been described as human pathogens in other countries. Rickettsia slovaca causes tick-borne lymphadenitis (TIBOLA). Rickettsia helvetica is a known pathogen of nonspecific fever; its role in endocarditis is still under investigation. Rickettsia felis causes so-called flea-borne spotted fever. Rickettsia monacensis and Rickettsia massiliae were recently shown to cause the classical form of tick-borne spotted fever. The sixth indigenous species in Germany, Rickettsia sp. RpA4, has not yet been associated with any human disease. The most important rickettsioses imported to Germany by travelers are African tick bite fever and Mediterranean spotted fever. Conclusions: Modern molecular biological techniques have enabled the detection of a number of rickettsial species in Germany. The medical importance of these illnesses in Germany remains to be determined. In travel medicine, imported rickettsioses play a role that should not be underestimated.
引用
收藏
页码:348 / 354
页数:7
相关论文
共 25 条
[1]  
BALESTRA GM, 2005, SCHWEIZ RUNDSCH MED, V94, P1869
[2]   RANDOMIZED TRIAL OF 5-DAY RIFAMPIN VERSUS 1-DAY DOXYCYCLINE THERAPY FOR MEDITERRANEAN SPOTTED-FEVER [J].
BELLA, F ;
ESPEJO, E ;
URIZ, S ;
SERRANO, JA ;
ALEGRE, MD ;
TORT, J .
JOURNAL OF INFECTIOUS DISEASES, 1991, 164 (02) :433-434
[3]   Clarithromycin versus azithromycin in the treatment of Mediterranean spotted fever in children: A randomized controlled trial [J].
Cascio, A ;
Colomba, C ;
Antinori, S ;
Paterson, DL ;
Titone, L .
CLINICAL INFECTIOUS DISEASES, 2002, 34 (02) :154-158
[4]  
DOBLER G, CLIN INFECT IN PRESS
[5]   Suicide PCR on skin biopsy specimens for diagnosis of rickettsioses [J].
Fournier, PE ;
Raoult, D .
JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (08) :3428-3434
[6]   Pathogens and symbionts in ticks:: prevalence of Anaplasma phagocytophilum (Ehrlichia sp.), Wolbachia sp., Rickettsia sp., and Babesia sp in Southern Germany [J].
Hartelt, K ;
Oehme, R ;
Frank, H ;
Brockmann, SO ;
Hassler, D ;
Kimmig, P .
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2004, 293 :86-92
[7]   Rickettsia monacensis and human disease, Spain [J].
Jado, Isabel ;
Oteo, Jose A. ;
Aldamiz, Mikel ;
Gil, Horacio ;
Escudero, Raquel ;
Ibarra, Valvanera ;
Portu, Joseba ;
Portillo, Aranzazu ;
Lezaun, Maria J. ;
Garcia-Amil, Cristina ;
Rodriguez-Moreno, Isabel ;
Anda, Pedro .
EMERGING INFECTIOUS DISEASES, 2007, 13 (09) :1405-1407
[8]  
Jelinek T, 2001, J TRAVEL MED, V8, P57, DOI 10.2310/7060.2001.24485
[9]   Rickettsioses and the international traveler [J].
Jensenius, M ;
Fournier, PE ;
Raoult, D .
CLINICAL INFECTIOUS DISEASES, 2004, 39 (10) :1493-1499
[10]  
LASCOLA B, 1996, J CLIN MICROBIOL, V34, P2723