A mitochondria-targeted iridium(iii)-based photoacid generator induces dual-mode photodynamic damage within cancer cells

被引：61

作者：

He, Liang ^{[1
,2
]}

Zhang, Ming-Fang ^{[2
]}

Pan, Zheng-Yin ^{[2
]}

Wang, Kang-Nan ^{[2
]}

Zhao, Zi-Jian ^{[2
]}

Li, Yi ^{[3
]}

Mao, Zong-Wan ^{[1
,2
]}

机构：

[1] South China Agr Univ, Coll Mat & Energy, Dept Appl Chem, Guangzhou 510642, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China

[3] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Minist Educ, Key Lab Theoret Organ Chem & Funct Mol, Xiangtan 411201, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 70期

基金：

中国国家自然科学基金;

关键词：

THERAPY; COMPLEXES; EFFICIENT; PHOTOSENSITIZER; NANOPARTICLES; HYPOXIA;

D O I：

10.1039/c9cc04871e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mitochondria-targeted photodynamic therapy (PDT) agent was designed and synthesized. Upon light irradiation, it can produce photoacid and its photolysis products can further sensitize O-1(2) generation, causing dual-mode (oxygen-independent and oxygen-dependent) photodynamic damage in mitochondria and killing cancer cells effectively even under hypoxic conditions.

引用

页码：10472 / 10475

页数：4