Natural history of gallbladder cancer. Analysis of biopsy specimens

被引:0
作者
Roa E, Ivan [1 ]
Munoz N, Sergio [2 ]
Ibacache S, Gilda
de Aretxabala U, Xabier [3 ]
机构
[1] Univ Desarrollo, Fac Med, Clin Alemana Santiago, Serv Anat Patol, Santiago, Chile
[2] Univ La Frontera, Fac Med, Ctr Invest & Gest Salud, Temuco, Chile
[3] Clin Alemana Santiago, Dept Cirugia, Santiago, Chile
关键词
Cholecystectomy; Gallbladder neoplasms; Metaplasia; HIGH-RISK AREA; BILIARY-TRACT; INTESTINAL METAPLASIA; PRENEOPLASTIC LESIONS; PRECURSOR LESIONS; EARLY CARCINOMA; CHILE; MORTALITY; ADENOMAS; DYSPLASIA;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: There is scarcity of knowledge about The development of gallbladder cancer. Aim: To study the feature of development and progression of gallbladder cancer. Material and methods: Review of histopathological studies of gallbladder obtained in 25,971 cholecytectomies performed in patients aged 45 +/- 16 years, 79% females, between 1995 and 2004. Among these, 210 bad a dysplasia not associated to cancer and 1,039 bad a gallbladder cancer Clinical and morphological parameters of Preneoplastic and neoplastic lesions were analyzed. Ninety five percent of patients were followed. Results: All cases of dysplasia were incidental findings. Metaplasia, dysplasia and carcinoma in situ were present in The adjacent mucosa in 66%, 81% y 69% of gallbladder carcinomas, respectively. Twenty five percent of gallbladders studied were carcinomas (mucous carcinoma in 18% and muscular carcinoma in 7%). Ninety two percent of cases bad chronic inflammation in The gallbladder wall. Seventy two percent of mucous carcinomas were not detected macroscopically. Five years survival of mucous carcinoma was 92%. There was an association between the intensity of the lesion. and the age of the patients. The age difference between chronic cholecystitis and gallbladder cancer was 11 year for women and nine for men. Conclusions: From a morphological standpoint, the period in which a a dysplasia becomes a carcinoma is approximately 10 year (Rev Med Chile 2009; 137: 873-80).
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页码:873 / 880
页数:8
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