Drug discovery and development for neglected parasitic diseases

被引：271

作者：

Renslo, Adam R. ^{[1
]}

McKerrow, James H.

机构：

[1] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Mol Discovery Ctr, San Francisco, CA 94158 USA

来源：

NATURE CHEMICAL BIOLOGY | 2006年 / 2卷 / 12期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nchembio837

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diseases caused by tropical parasites affect hundreds of millions of people worldwide but have been largely neglected for drug development because they affect poor people in poor regions of the world. Most of the current drugs used to treat these diseases are decades old and have many limitations, including the emergence of drug resistance. This review will summarize efforts to reinvigorate the drug development pipeline for these diseases, which is driven in large part by support from major philanthropies. The organisms responsible for these diseases have a fascinating biology, and many potential biochemical targets are now apparent. These neglected diseases present unique challenges to drug development that are being addressed by new consortia of scientists from academia and industry.

引用

页码：701 / 710

页数：10

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