Estimated cognitive decline in patients with schizophrenia: A multicenter study

被引：57

作者：

Fujino, Haruo ^{[1
,2
]}

Sumiyoshi, Chika ^{[3
]}

Yasuda, Yuka ^{[4
]}

Yamamori, Hidenaga ^{[4
]}

Fujimoto, Michiko ^{[4
]}

Fukunaga, Masaki ^{[5
]}

Miura, Kenichiro ^{[6
]}

Takebayashi, Yuto ^{[7
]}

Okada, Naohiro ^{[8
]}

Isomura, Shuichi ^{[9
]}

Kawano, Naoko ^{[10
,11
]}

Toyomaki, Atsuhito ^{[12
]}

Kuga, Hironori ^{[9
,13
]}

Isobe, Masanori ^{[14
]}

Oya, Kazuto ^{[15
]}

Okahisa, Yuko ^{[16
]}

Takaki, Manabu ^{[16
]}

Hashimoto, Naoki ^{[12
]}

Kato, Masaki ^{[17
]}

Onitsuka, Toshiaki ^{[9
]}

Ueno, Takefumi ^{[9
,13
]}

Ohnuma, Tohru ^{[7
]}

Kasai, Kiyoto ^{[8
]}

Ozaki, Norio ^{[11
]}

Sumiyoshi, Tomiki ^{[18
]}

Imura, Osamu ^{[1
]}

Hashimoto, Ryota ^{[4
,19
]}

机构：

[1] Osaka Univ, Grad Sch Human Sci, Osaka, Japan

[2] Oita Univ, Grad Sch Educ, Oita, Japan

[3] Fukushima Univ, Fac Human Dev & Culture, Fukushima, Japan

[4] Osaka Univ, Grad Sch Med, Dept Psychiat, Osaka, Japan

[5] Natl Inst Physiol Sci, Div Cerebral Integrat, Okazaki, Aichi, Japan

[6] Kyoto Univ, Grad Sch Med, Dept Integrat Brain Sci, Kyoto, Japan

[7] Juntendo Univ, Fac Med, Dept Psychiat, Tokyo, Japan

[8] Univ Tokyo, Dept Neuropsychiat, Grad Sch Med, Tokyo, Japan

[9] Kyushu Univ, Grad Sch Med Sci, Dept Neuropsychiat, Fukuoka, Japan

[10] Nagoya Univ, Inst Innovat Future Soc, Green Mobil Res Inst, Nagoya, Aichi, Japan

[11] Nagoya Univ, Grad Sch Med, Dept Psychiat, Nagoya, Aichi, Japan

[12] Hokkaido Univ, Grad Sch Med, Dept Psychiat, Sapporo, Hokkaido, Japan

[13] Natl Hosp Org, Hizen Psychiat Ctr, Div Clin Res, Saga, Japan

[14] Kyoto Univ, Grad Sch Med, Dept Psychiat, Kyoto, Japan

[15] Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi, Japan

[16] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat, Okayama, Japan

[17] Kansai Med Univ, Dept Neuropsychiat, Osaka, Japan

[18] Natl Ctr Neurol & Psychiat, Translat Med Ctr, Dept Clin Epidemiol, Tokyo, Japan

[19] Osaka Univ, United Grad Sch Child Dev, Mol Res Ctr Childrens Mental Dev, D3,2-2 Yamadaoka, Suita, Osaka 5650871, Japan

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 2017年 / 71卷 / 05期

基金：

日本学术振兴会;

关键词：

cognition; cognitive decline; intelligence; multicenter study; schizophrenia; NEAR-INFRARED SPECTROSCOPY; GENOME-WIDE ASSOCIATION; 1ST-EPISODE SCHIZOPHRENIA; COMPROMISED INTELLECT; PREFRONTAL CORTEX; JAPANESE PATIENTS; FLUENCY TASK; IQ DECLINE; INTELLIGENCE; IMPAIRMENT;

D O I：

10.1111/pcn.12474

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Aim: Studies have reported that cognitive decline occurs after the onset of schizophrenia despite heterogeneity in cognitive function among patients. The aim of this study was to investigate the degree of estimated cognitive decline in patients with schizophrenia by comparing estimated premorbid intellectual functioning and current intellectual functioning. Methods: A total of 446 patients with schizophrenia (228 male, 218 female), consisting of three sample sets obtained from 11 psychiatric facilities, and 686 healthy controls participated in this study. The Wechsler Adult Intelligence Scale-III (WAIS-III) was used to measure the participants' current full-scale IQ (FSIQ). The premorbid IQ was estimated using the Japanese Adult Reading Test-25. Estimated cognitive decline (difference score) was defined as the difference between the estimated premorbid IQ and the current FSIQ. Results: Patients with schizophrenia showed greater estimated cognitive decline, a lower FSIQ, and a lower premorbid IQ compared with the healthy controls. The mean difference score, FSIQ, and estimated premorbid IQ were -16.3, 84.2, and 100.5, respectively, in patients with schizophrenia. Furthermore, 39.7% of the patients had a difference score of 20 points or greater decline. A discriminant analysis showed that the difference score accurately predicted 81.6% of the patients and healthy controls. Conclusion: These results show the distribution of difference score in patients with schizophrenia. These findings may contribute to assessing the severity of estimated cognitive decline and identifying patients with schizophrenia who suffer from cognitive decline.

引用

页码：294 / 300

页数：7

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