Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021

被引：210
作者：
Abu Jabal, Kamal [1 ,2 ]
Ben-Amram, Hila [2 ]
Beiruti, Karine [2 ]
Batheesh, Yunis [2 ]
Sussan, Christian [2 ]
Zarka, Salman [1 ,2 ]
Edelstein, Michael [1 ,2 ]
机构：
[1] Ziv Med Ctr, Safed, Israel
[2] Bar Ilan Univ, Azrieli Fac Med, Safed, Israel
来源：
EUROSURVEILLANCE | 2021年 / 26卷 / 06期
关键词：
D O I：
10.2807/1560-7917.ES.2021.26.6.2100096
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The BNT162b2 mRNA COVID-19 vaccine showed high efficacy in clinical trials but observational data from populations not included in trials are needed. We describe immunogenicity 21 days post-dose among 514 Israeli healthcare workers by age, ethnicity, sex and prior COVID-19 infection. Immunogenicity was similar by ethnicity and sex but decreased with age. Those with prior infection had antibody titres one magnitude order higher than naive individuals regardless of the presence of detectable IgG antibodies pre-vaccination.
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