A neural basis for the development of inhibitory control

被引:460
作者
Durston, S
Thomas, KM
Yang, YH
Ulug, AM
Zimmerman, RD
Casey, BJ
机构
[1] Cornell Univ, Weill Med Coll, Sackler Inst Dev Psychobiol, New York, NY 10021 USA
[2] Univ Utrecht, Ctr Med, Dept Child & Adolescent Psychiat, Utrecht, Netherlands
[3] Cornell Univ, Weill Med Coll, Dept Psychiat, New York, NY USA
[4] Cornell Univ, Weill Med Coll, Dept Radiol, New York, NY USA
关键词
D O I
10.1111/1467-7687.00235
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
The present study explores the neural basis of the development of inhibitory, control by combining functional neuroimaging with a parametric manipulation of a go-nogo paradigm. We demonstrate how the maturation of ventral fronto-striatal circuitry underlies the development of this ability. We used event-related fMRI to examine the effect of interference on neural processes involved in inhibitory control in children and adults. Nogo trials were preceded by either 1, 3 or 5 go trials and then compared to one another. Both children and adults showed an increase in errors with increasing interference. Successful response inhibition was associated with stronger activation of prefrontal and parietal regions for children than for adults. In adults, activation in ventral prefrontal regions increased with increasing interference from go trials. Unlike adults, the circuitry appeared to be maximally activated in children when suppressing a behavioral response regardless of the number of preceding responses. Furthermore, activation in ventral fronto-striatal regions correlated with both age and performance. These findings suggest that immature cognition is more susceptible to interference and this is paralleled by maturational differences in underlying fronto-striatal circuitry.
引用
收藏
页码:F9 / F16
页数:8
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