The Gene Ontology resource: enriching a GOld mine

被引：2167

作者：

Carbon, Seth ^{[1
]}

Douglass, Eric ^{[1
]}

Good, Benjamin M. ^{[1
]}

Unni, Deepak R. ^{[1
]}

Harris, Nomi L. ^{[1
]}

Mungall, Christopher J. ^{[1
]}

Basu, Siddartha ^{[2
]}

Chisholm, Rex L. ^{[2
]}

Dodson, Robert J. ^{[2
]}

Hartline, Eric ^{[2
]}

Fey, Petra ^{[2
]}

Thomas, Paul D. ^{[3
]}

Albou, Laurent-Philippe ^{[3
]}

Ebert, Dustin ^{[3
]}

Kesling, Michael J. ^{[3
]}

Mi, Huaiyu ^{[3
]}

Muruganujan, Anushya ^{[3
]}

Huang, Xiaosong ^{[3
]}

Mushayahama, Tremayne ^{[3
]}

LaBonte, Sandra A. ^{[4
,5
]}

Siegele, Deborah A. ^{[4
,5
]}

Antonazzo, Giulia ^{[6
]}

Attrill, Helen ^{[6
]}

Brown, Nick H. ^{[6
]}

Garapati, Phani ^{[6
]}

Marygold, Steven J. ^{[6
]}

Trovisco, Vitor ^{[6
]}

Dos Santos, Gil ^{[7
]}

Falls, Kathleen ^{[7
]}

Tabone, Christopher ^{[7
]}

Zhou, Pinglei ^{[7
]}

Goodman, Joshua L. ^{[8
]}

Strelets, Victor B. ^{[8
]}

Thurmond, Jim ^{[8
]}

Garmiri, Penelope ^{[9
]}

Ishtiaq, Rizwan ^{[9
]}

Rodriguez-Lopez, Milagros ^{[9
]}

Acencio, Marcio L. ^{[10
]}

Kuiper, Martin ^{[10
]}

Laegreid, Astrid ^{[10
]}

Logie, Colin ^{[11
]}

Lovering, Ruth C. ^{[12
]}

Kramarz, Barbara ^{[12
]}

Saverimuttu, Shirin C. C. ^{[12
]}

Pinheiro, Sandra M. ^{[12
]}

Gunn, Heather ^{[12
]}

Su, Renzhi ^{[12
]}

Thurlow, Katherine E. ^{[12
]}

Chibucos, Marcus ^{[13
]}

Giglio, Michelle ^{[13
]}

机构：

[1] Lawrence Berkeley Natl Lab, Berkeley Bioinformat Open Source Projects BBOP, Environm Genom & Syst Biol Div, Berkeley, CA USA

[2] Northwestern Univ, DictyBase, Chicago, IL 60611 USA

[3] Univ Southern Calif, Div Bioinformat, Dept Prevent Med, Los Angeles, CA 90007 USA

[4] Texas A&M Univ, Dept Biol, EcoliWiki, College Stn, TX 77843 USA

[5] Texas A&M Univ, Dept Biochem & Biophys, EcoliWiki, College Stn, TX 77843 USA

[6] Univ Cambridge, Dept Physiol Dev & Neurosci, FlyBase, Cambridge, England

[7] Harvard Univ, Biol Labs, FlyBase, Cambridge, MA 02138 USA

[8] Indiana Univ, Dept Biol, FlyBase, Bloomington, IL USA

[9] GO EMBL EBI, Hinxton, England

[10] Norwegian Univ Sci & Uchnol, Gene Regulat Consortium GRECO, Trondheim, Norway

[11] Radboud Univ Nijmegen, Gene Regulat Consortium GRECO, Nijmegen, Netherlands

[12] UCL, Inst Cardiovasc Sci, Funct Gene Annotat, London, England

[13] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA

[14] EMBL EBI, IntAct Complex Portal, Hinxton, England

[15] EMBL EBI, Interpro, Hinxton, England

[16] Jackson Lab, Mouse Genome Informat, 600 Main St, Bar Harbor, ME 04609 USA

[17] Univ Cambridge, PomBase, Cambridge, England

[18] Francis Crick Inst, PomBase, London, England

[19] UCL, PomBase, London, England

[20] Med Coll Wisconsin, Milwaukee, WI 53226 USA

[21] NYU, Grossman Sch Med, Dept Biochem & Mol Pharmacol, New York, NY USA

[22] Univ N Carolina, Renaissance Comp Inst, Chapel Hill, NC USA

[23] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

[24] SIB Swiss Inst Bioinformat, Geneva, Switzerland

[25] Phoenix Bioinformat, Arabidopsis Informat Resource TAIR, Fremont, CA USA

[26] EMBI EBI, UniProt, Hinxton, England

[27] SIB Swiss Inst Bioinformat SIB, Geneva, Switzerland

[28] Prot Informat Resource PIR, Washington, DC USA

[29] Univ Buffalo, Dept Biomed Informat, Buffalo, NY USA

[30] CALTECH, WormBase, Pasadena, CA USA

[31] Wellcome Trust Sanger Inst, Hinxton, England

[32] EBI, Hinxton, England

[33] Ontario Inst Canc Res, Toronto, ON, Canada

[34] Univ Oregon, ZFIN, Eugene, OR 97403 USA

[35] Planteome, Corvallis, OR USA

[36] Oregon State Univ, Corvallis, OR 97331 USA

来源：

NUCLEIC ACIDS RESEARCH | 2021年 / 49卷 / D1期

基金：

英国惠康基金; 英国医学研究理事会; 英国生物技术与生命科学研究理事会; 美国国家科学基金会; 美国国家卫生研究院;

关键词：

ANNOTATION;

D O I：

10.1093/nar/gkaa1113

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two years. The new GO-CAM annotation framework was notably improved, and we formalized the model with a computational schema to check and validate the rapidly increasing repository of 2838 GO-CAMs. In addition, we describe the impacts of several collaborations to refine GO and report a 10% increase in the number of GO annotations, a 25% increase in annotated gene products, and over 9,400 new scientific articles annotated. As the project matures, we continue our efforts to review older annotations in light of newer findings, and, to maintain consistency with other ontologies. As a result, 20 000 annotations derived from experimental data were reviewed, corresponding to 2.5% of experimental GO annotations. The website (http://geneontology.org) was redesigned for quick access to documentation, downloads and tools. To maintain an accurate resource and support traceability and reproducibility, we have made available a historical archive covering the past 15 years of GO data with a consistent format and file structure for both the ontology and annotations.

引用

页码：D325 / D334

页数：10

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