DNA sequences from mobile genetic elements, a hidden half of the human genome

被引：8
作者：
Medina, Julie [1 ]
Perron, Herve [1 ,2 ,3 ]
机构：
[1] GeNeuro Innovat, Bioparc Laennec,60,Ave Rockefeller, F-69008 Lyon, France
[2] GeNeuro, 18 Chemin Aulx,1228 Plan Les Ouates, Geneva, Switzerland
[3] Univ Lyon 1, Fac Med Laennec, F-69008 Lyon, France
来源：
M S-MEDECINE SCIENCES | 2017年 / 33卷 / 02期
关键词：
HUMAN ENDOGENOUS RETROVIRUSES; HUMAN-POPULATIONS; MAMMARY-TUMOR; W ELEMENTS; INSERTIONS; EVOLUTION; DISEASE; ENDOGENIZATION; CLASSIFICATION; EXPRESSION;
D O I：
10.1051/medsci/20173302010
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Current data estimate that mobile genetic elements represent more than one-half of the human genome. The literature is constantly updating data following the evolution of sequencing techniques and of algorithms for genome analyses. This review aims to provide an overview of the topic showing the complexity given by the various designations and classifications found in scientific papers. A particular focus is made on retrotransposons, including Endogenous RetroViruses (ERV), to introduce a second article focusing on their activation and their involvement in physiological functions and/or pathological mechanisms associated with diseases like multiple sclerosis (MS) or amyotrophic lateral sclerosis (ALS).
引用
收藏
页码：151 / 158
页数：8
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