Hypoxia enhances the protective effects of placenta-derived mesenchymal stem cells against scar formation through hypoxia-inducible factor-1α

被引：7
作者：
Du, Lili [1 ]
Lv, Runxiao [2 ,3 ]
Yang, Xiaoyi [4 ]
Cheng, Shaohang [5 ]
Xu, Jing [5 ]
Ma, Tingxian [1 ]
机构：
[1] China Med Univ, Dept Pathophysiol, Coll Basic Med Sci, 77 Puhe Rd, Shenyang 110122, Peoples R China
[2] Second Mil Med Univ, Grad Management Unit, Shanghai 200433, Peoples R China
[3] Second Mil Med Univ, Changhai Hosp, Dept Orthoped, Shanghai 200433, Peoples R China
[4] China Med Univ, Year Syst 7, Med Clin, Shenyang 110122, Peoples R China
[5] China Med Univ, Shengjing Hosp, Dept Dermatol, Shenyang 110004, Peoples R China
来源：
BIOTECHNOLOGY LETTERS | 2016年 / 38卷 / 06期
关键词：
Collagen; Hypoxia; Hypoxia-inducible factor-1 alpha; Inflammation; Placenta-derived mesenchymal stem cells; Scar formation; RATS; SKIN;
D O I：
10.1007/s10529-016-2067-6
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
To explore the effect of placenta-derived mesenchymal stem cells on scar formation as well as the underlying mechanism. The isolated placenta-derived mesenchymal stem cells from mice were distributed in the wounded areas of scalded mouse models, attenuated inflammatory responses and decreased the deposition of collagens, thus performing a beneficial effect against scar formation. Hypoxia enhanced the protective effect of placenta-derived mesenchymal stem cells and hypoxia-inducible factor-1 alpha was involved in the protective effect of placenta-derived mesenchymal stem cells in hypoxic condition. Hypoxia enhanced the protective effect of placenta-derived mesenchymal stem cells through hypoxia-inducible factor-1 alpha and PMSCs may have a potential application in the treatment of wound.
引用
收藏
页码：931 / 939
页数：9
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