Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice

被引：25

作者：

Sun, Liou Y. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Pediat, Div Endocrinol, Chapel Hill, NC 27599 USA

来源：

AGE | 2006年 / 28卷 / 02期

关键词：

growth hormone; insulin-like growth factor I; thymidine analogue 5 '-bromo-2-deoxyuridine; subgranular zone; dentate gyrus; pituitary-specific transcription factor; granule cell layer;

D O I：

10.1007/s11357-006-9009-5

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Recent studies point out the important role of IGF and insulin-related signaling pathways in the control of longevity of laboratory animals. The Ames dwarf mouse is a murine model of circulating GH and IGF-1 deficiency that exhibits dwarf phenotype characteristics and significantly extends lifespan. It is interesting to know that Ames dwarf mice do not experience an age-related decline in cognitive function when compared to their young counterparts. In this study, the most recent works on local GH and IGF-1 expression in the hippocampus of Ames mice are briefly reviewed.

引用

页码：181 / 189

页数：9