Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice

被引：25
|
作者：
Sun, Liou Y. [1 ]
机构：
[1] Univ N Carolina, Dept Pediat, Div Endocrinol, Chapel Hill, NC 27599 USA
来源：
AGE | 2006年 / 28卷 / 02期
关键词：
growth hormone; insulin-like growth factor I; thymidine analogue 5 '-bromo-2-deoxyuridine; subgranular zone; dentate gyrus; pituitary-specific transcription factor; granule cell layer;
D O I：
10.1007/s11357-006-9009-5
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Recent studies point out the important role of IGF and insulin-related signaling pathways in the control of longevity of laboratory animals. The Ames dwarf mouse is a murine model of circulating GH and IGF-1 deficiency that exhibits dwarf phenotype characteristics and significantly extends lifespan. It is interesting to know that Ames dwarf mice do not experience an age-related decline in cognitive function when compared to their young counterparts. In this study, the most recent works on local GH and IGF-1 expression in the hippocampus of Ames mice are briefly reviewed.
引用
收藏
页码：181 / 189
页数：9
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