Abastract Plasmonic nanomaterials, especially a wide variety of gold nanoparticles, demonstrate great potential for theranostics of cancer. Herein, a gold nanotriangle with CD133 and hyaluronic acid on its surface loaded with a near-infrared photosensitizer was prepared for enhanced photodynamic/photothermal combined anti-tumor therapy. CD133 and hyaluronic acid provide the nanoprobe with dual tumor targeting, while the hyaluronic acid also protects photosensitive drugs from photodegradation. Thus, the nanoprobe has enhanced photothermal/photodynamic effects. This integrated treatment strategy significantly enhanced photodynamic/photothermal destruction of osteosarcoma cells. In addition, this treatment, induced by mild irradiation with a single wavelength laser, inhibited tumor growth in an osteosarcoma mouse model. These results indicate that this systemic treatment strategy can achieve enhanced anti-tumor therapeutic effects through active tumor targeting and protection of the loaded drugs.
机构:
Sichuan Univ, West China Hosp, Dept Gen Surg, Div Biliary Surg, 37 Guoxue Lane, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Res Ctr Biliary Dis, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Dept Gen Surg, Div Biliary Surg, 37 Guoxue Lane, Chengdu 610041, Peoples R China
Li, Bei
Ye, Xiwen
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Sichuan Univ, West China Hosp, Dept Gen Surg, Div Biliary Surg, 37 Guoxue Lane, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Dept Gen Surg, Div Biliary Surg, 37 Guoxue Lane, Chengdu 610041, Peoples R China
Ye, Xiwen
Fu, Yi
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Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R ChinaSichuan Univ, West China Hosp, Dept Gen Surg, Div Biliary Surg, 37 Guoxue Lane, Chengdu 610041, Peoples R China
Fu, Yi
Feng, Lei
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Sichuan Univ, West China Hosp, Dept Gen Surg, Div Biliary Surg, 37 Guoxue Lane, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Dept Gen Surg, Div Biliary Surg, 37 Guoxue Lane, Chengdu 610041, Peoples R China
Feng, Lei
Xu, Jianrong
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Sichuan Univ, West China Hosp, Res Ctr Biliary Dis, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Dept Gen Surg, Div Biliary Surg, 37 Guoxue Lane, Chengdu 610041, Peoples R China
Xu, Jianrong
Niu, Xiaoya
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Sichuan Univ, West China Hosp, Dept Gen Surg, Div Biliary Surg, 37 Guoxue Lane, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Dept Gen Surg, Div Biliary Surg, 37 Guoxue Lane, Chengdu 610041, Peoples R China
Niu, Xiaoya
Ye, Hui
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Sichuan Univ, West China Hosp, Dept Gen Surg, Div Biliary Surg, 37 Guoxue Lane, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Dept Gen Surg, Div Biliary Surg, 37 Guoxue Lane, Chengdu 610041, Peoples R China
Ye, Hui
You, Zhen
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机构:
Sichuan Univ, West China Hosp, Dept Gen Surg, Div Biliary Surg, 37 Guoxue Lane, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Res Ctr Biliary Dis, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Dept Gen Surg, Div Biliary Surg, 37 Guoxue Lane, Chengdu 610041, Peoples R China