Gold nanoparticle-based nanoprobes with enhanced tumor targeting and photothermal/photodynamic response for therapy of osteosarcoma

被引:21
作者
Xiong, Shengren [1 ]
Xiong, Guosheng [1 ]
Li, Zhaohui [1 ]
Jiang, Qing [2 ]
Yin, Jia [3 ]
Yin, Ting [4 ]
Zheng, Hong [1 ]
机构
[1] Xiamen Univ, Fuzhou Hosp 2, Fuzhou 350007, Fujian, Peoples R China
[2] Fuzhou Tradit Chinese Med Hosp, Fuzhou 350001, Fujian, Peoples R China
[3] Chinese Acad Sci, Shenzhen Inst Adv Technol SIAT, Shenzhen 518055, Peoples R China
[4] Guangdong Med Univ, Key Lab Nanomed, Dongguan Key Lab Drug Design & Formulat Technol, Dongguan 523808, Peoples R China
基金
中国国家自然科学基金;
关键词
gold nanoparticle; CD133; tumor targeting; photothermal; photodynamic therapy; osteosarcoma; PHOTODYNAMIC THERAPY; CELLS; CONVERSION; SURVIVAL; ACID;
D O I
10.1088/1361-6528/abd816
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Abastract Plasmonic nanomaterials, especially a wide variety of gold nanoparticles, demonstrate great potential for theranostics of cancer. Herein, a gold nanotriangle with CD133 and hyaluronic acid on its surface loaded with a near-infrared photosensitizer was prepared for enhanced photodynamic/photothermal combined anti-tumor therapy. CD133 and hyaluronic acid provide the nanoprobe with dual tumor targeting, while the hyaluronic acid also protects photosensitive drugs from photodegradation. Thus, the nanoprobe has enhanced photothermal/photodynamic effects. This integrated treatment strategy significantly enhanced photodynamic/photothermal destruction of osteosarcoma cells. In addition, this treatment, induced by mild irradiation with a single wavelength laser, inhibited tumor growth in an osteosarcoma mouse model. These results indicate that this systemic treatment strategy can achieve enhanced anti-tumor therapeutic effects through active tumor targeting and protection of the loaded drugs.
引用
收藏
页数:11
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