Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin

被引：135

作者：

Ray, Balmiki ^{[1
]}

Lahiri, Debomoy K. ^{[1
,2
]}

机构：

[1] Indiana Univ, Sch Med, Mol Neurogenet Lab, Dept Psychiat,Inst Psychiat Res, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2009年 / 9卷 / 04期

基金：

美国国家卫生研究院;

关键词：

AMYLOID PRECURSOR PROTEIN; NF-KAPPA-B; APOLIPOPROTEIN-E; CLINICAL-TRIAL; ACETYLCHOLINESTERASE INHIBITOR; COGNITIVE DEFICITS; OXIDATIVE DAMAGE; GENE-EXPRESSION; BETA-PEPTIDES; ACTIVATION;

D O I：

10.1016/j.coph.2009.06.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Alzheimer's disease (AD) is a neurodegenerative disorder of the elderly. Deposition of amyloid beta plaque and associated neuroinflammation are the major hallmarks of AD. Whereas reactive oxygen species (ROS) and activated microglial cells contribute to neuronal loss, nuclear factor kappa B and apolipoprotein E participate in inflammatory process of AD. Current FDA approved drugs provide only symptomatic relief in AD. For broad spectrum of activity, some natural products are also being tested. Turmeric is used as an anti-inflammatory medicine in various regions of Asia. Curcumin, which is a yellow colored polyphenol compound present in turmeric, showed anti-inflammatory properties. Herein, we discuss the neurobiological and neuroinflammatory pathways of AD, evaluate different molecular targets and potential therapeutic agents, including curcumin, for the treatment of AD.

引用

页码：434 / 444

页数：11

共 70 条

[1] Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease [J].