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Ni-Catalyzed enantioselective reductive aryl-alkenylation of alkenes: application to the synthesis of (+)-physovenine and (+)-physostigmine
被引:63
作者:
Li, Yuxiu
[1
]
Ding, Zhengtian
[1
]
Lei, Aiwen
[1
]
Kong, Wangqing
[1
]
机构:
[1] Wuhan Univ, Coll Chem & Mol Sci, IAS, Wuhan 430072, Hubei, Peoples R China
基金:
中国国家自然科学基金;
关键词:
CROSS-COUPLING REACTIONS;
ANION CAPTURE PROCESSES;
FORMAL TOTAL SYNTHESIS;
ASYMMETRIC-SYNTHESIS;
CALABAR ALKALOIDS;
CYCLIZATION;
OXINDOLES;
HALIDES;
ROUTE;
DICARBOFUNCTIONALIZATION;
D O I:
10.1039/c9qo00744j
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
A Ni-catalyzed enantioselective reductive aryl-alkenylation of alkenes by cyclizative coupling of an aryl bromide and a vinyl bromide is developed, providing efficient access to functionalized 3,3-disubstituted oxindoles under mild conditions, without requiring the use of preformed vinylmetallic reagents. With this method, a concise formal synthesis of (+)-physovenine and (+)-physostigmine has been completed.
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页码:3305 / 3309
页数:5
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