Ni-Catalyzed enantioselective reductive aryl-alkenylation of alkenes: application to the synthesis of (+)-physovenine and (+)-physostigmine

被引:63
作者
Li, Yuxiu [1 ]
Ding, Zhengtian [1 ]
Lei, Aiwen [1 ]
Kong, Wangqing [1 ]
机构
[1] Wuhan Univ, Coll Chem & Mol Sci, IAS, Wuhan 430072, Hubei, Peoples R China
基金
中国国家自然科学基金;
关键词
CROSS-COUPLING REACTIONS; ANION CAPTURE PROCESSES; FORMAL TOTAL SYNTHESIS; ASYMMETRIC-SYNTHESIS; CALABAR ALKALOIDS; CYCLIZATION; OXINDOLES; HALIDES; ROUTE; DICARBOFUNCTIONALIZATION;
D O I
10.1039/c9qo00744j
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A Ni-catalyzed enantioselective reductive aryl-alkenylation of alkenes by cyclizative coupling of an aryl bromide and a vinyl bromide is developed, providing efficient access to functionalized 3,3-disubstituted oxindoles under mild conditions, without requiring the use of preformed vinylmetallic reagents. With this method, a concise formal synthesis of (+)-physovenine and (+)-physostigmine has been completed.
引用
收藏
页码:3305 / 3309
页数:5
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