A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring

被引：23

作者：

Ponce, Alex T. ^{[1
]}

Hong, Ka Lok ^{[1
]}

机构：

[1] Wilkes Univ, Dept Pharmaceut Sci, Nesbitt Sch Pharm, 84 W South St, Wilkes Barre, PA 18766 USA

来源：

BIOMEDICINES | 2019年 / 7卷 / 03期

关键词：

thrombotic event; aptamer; DNA; RNA; SELEX; molecular recognition element (MRE); monitoring; treatment; WILLEBRAND-FACTOR A1-DOMAIN; DIRECT ORAL ANTICOAGULANTS; EXPONENTIAL ENRICHMENT; SYSTEMATIC EVOLUTION; INHIBITS THROMBIN; HIGH-AFFINITY; GENERATION; SELECTION; LIGANDS; COAGULATION;

D O I：

10.3390/biomedicines7030055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The unique opportunity for aptamer uses in thrombotic events has sparked a considerable amount of research in the area. The short half-lives of unmodified aptamers in vivo remain one of the major challenges in therapeutic aptamers. Much of the incremental successful therapeutic aptamer stories were due to modifications in the aptamer bases. This mini-review briefly summarizes the successes and challenges in the clinical development of aptamers for thrombotic events, and highlights some of the most recent developments in using aptamers for anticoagulation monitoring.

引用

页数：15

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