Cationic Antimicrobial Peptides for Tuberculosis: A Mini-Review

被引：3
作者：
Silva, Sara [1 ,2 ,3 ]
Vale, Nuno [1 ,2 ,3 ,4 ]
机构：
[1] Univ Porto, Fac Pharm, Dept Drug Sci, Pharmacol Lab, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal
[2] Univ Porto IPATIMUP, Inst Mol Pathol & Immunol, Rua Julio Amaral de Carvalho 45, P-4200135 Porto, Portugal
[3] Univ Porto, i3S, Rua Alfredo Allen 208, P-4200135 Porto, Portugal
[4] Univ Porto, Inst Biomed Sci Abel Salazar ICBAS, Dept Mol Pathol & Immunol, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal
来源：
CURRENT PROTEIN & PEPTIDE SCIENCE | 2019年 / 20卷 / 09期
关键词：
Tuberculosis; Mycobacterium tuberculosis; antimicrobial peptides; natural CAMPs; synthetic CAMPs; HOST-DEFENSE PEPTIDES; IN-VITRO ACTIVITY; MYCOBACTERIUM-TUBERCULOSIS; ANTIBACTERIAL; DESIGN;
D O I：
10.2174/1389203720666190626160057
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cationic antimicrobial peptides (CAMPs) can be considered as new potential therapeutic agents for Tuberculosis treatment with a specific amino acid sequence. New studies can be developed in the future to improve the pharmacological properties of CAMPs and also understand possible resistance mechanisms. This review discusses the principal properties of natural and/or synthetic CAMPs, and how these new peptides have a significant specificity for Mycobacterium tuberculosis. Also, we propose some alternative strategies to enhance the therapeutic activity of these CAMPs that include co-administration with nanoparticles and/or classic drugs.
引用
收藏
页码：885 / 892
页数：8
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