A High-Precision Machine Learning Algorithm to Classify Left and Right Outflow Tract Ventricular Tachycardia

被引：19

作者：

Zheng, Jianwei ^{[1
]}

Fu, Guohua ^{[2
]}

Abudayyeh, Islam ^{[3
]}

Yacoub, Magdi ^{[4
]}

Chang, Anthony ^{[5
]}

Feaster, William W. ^{[5
]}

Ehwerhemuepha, Louis ^{[5
]}

El-Askary, Hesham ^{[1
,6
]}

Du, Xianfeng ^{[2
]}

He, Bin ^{[2
]}

Feng, Mingjun ^{[2
]}

Yu, Yibo ^{[2
]}

Wang, Binhao ^{[2
]}

Liu, Jing ^{[2
]}

Yao, Hai ^{[7
]}

Chu, Huimin ^{[2
]}

Rakovski, Cyril ^{[1
]}

机构：

[1] Chapman Univ, Computat & Data Sci, Orange, CA USA

[2] Ningbo First Hosp Zhejiang Univ, Dept Cardiol, Hangzhou, Peoples R China

[3] Loma Linda Univ, Dept Cardiol, Loma Linda, CA USA

[4] Imperial Coll London, Harefield Heart Sci Ctr, London, England

[5] CHOC Childrens Hosp, Orange, CA USA

[6] Alexandria Univ, Dept Environm Sci, Fac Sci, Alexandria, Egypt

[7] Zhejiang Cachet Jetboom Med Devices Co Ltd, Hangzhou, Peoples R China

来源：

FRONTIERS IN PHYSIOLOGY | 2021年 / 12卷

关键词：

outflow tract ventricular tachycardia; catheter ablation; electrocardiography; classification; artificial intelligence algorithm; OPTIMAL ABLATION SITE; ELECTROCARDIOGRAPHIC CRITERION; ECG ALGORITHM; ORIGIN; TRANSITION; LEAD;

D O I：

10.3389/fphys.2021.641066

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Introduction Multiple algorithms based on 12-lead ECG measurements have been proposed to identify the right ventricular outflow tract (RVOT) and left ventricular outflow tract (LVOT) locations from which ventricular tachycardia (VT) and frequent premature ventricular complex (PVC) originate. However, a clinical-grade machine learning algorithm that automatically analyzes characteristics of 12-lead ECGs and predicts RVOT or LVOT origins of VT and PVC is not currently available. The effective ablation sites of RVOT and LVOT, confirmed by a successful ablation procedure, provide evidence to create RVOT and LVOT labels for the machine learning model. Methods We randomly sampled training, validation, and testing data sets from 420 patients who underwent successful catheter ablation (CA) to treat VT or PVC, containing 340 (81%), 38 (9%), and 42 (10%) patients, respectively. We iteratively trained a machine learning algorithm supplied with 1,600,800 features extracted via our proprietary algorithm from 12-lead ECGs of the patients in the training cohort. The area under the curve (AUC) of the receiver operating characteristic curve was calculated from the internal validation data set to choose an optimal discretization cutoff threshold. Results The proposed approach attained the following performance: accuracy (ACC) of 97.62 (87.44-99.99), weighted F1-score of 98.46 (90-100), AUC of 98.99 (96.89-100), sensitivity (SE) of 96.97 (82.54-99.89), and specificity (SP) of 100 (62.97-100). Conclusions The proposed multistage diagnostic scheme attained clinical-grade precision of prediction for LVOT and RVOT locations of VT origin with fewer applicability restrictions than prior studies.

引用

页数：12