Impact of COVID-19 in the Mental Health in Elderly: Psychological and Biological Updates

被引：109

作者：

Grolli, Roberta Eduarda ^{[1
,2
]}

Mingoti, Maiqueli Eduarda Dama ^{[1
,2
]}

Bertollo, Amanda Gollo ^{[1
,2
]}

Luzardo, Adriana Remiao ^{[1
,3
]}

Quevedo, Joao ^{[4
,5
,6
,7
]}

Reus, Gislaine Zilli ^{[4
]}

Ignacio, Zuleide Maria ^{[1
,2
,4
]}

机构：

[1] Fed Univ Southern Frontier, Undergrad Nursing Course, Chapeco, SC, Brazil

[2] Fed Univ Southern Frontier, Postgrad Program Biomed Sci, Lab Physiol, Pharmacol,Psychopathol, Chapeco, SC, Brazil

[3] Fed Univ Southern Frontier, Lab Innovat & Hlth Technol, Chapeco, SC, Brazil

[4] Univ Southern Santa Catarina, Grad Program Hlth Sci, Lab Translat Psychiat, Criciuma, SC, Brazil

[5] Univ Texas Hlth Sci Ctr Houston UTHlth, McGovern Med Sch, Faillace Dept Psychiat & Behav Sci, Ctr Excellence Mood Disorders, Houston, TX USA

[6] Univ Texas Hlth Sci Ctr Houston UTHlth, McGovern Med Sch, Faillace Dept Psychiat & Behav Sci, Translat Psychiat Program, Houston, TX USA

[7] Univ Texas Hlth Sci Ctr Houston UTHlth, Grad Sch Biomed Sci, Neurosci Grad Program, Houston, TX USA

来源：

MOLECULAR NEUROBIOLOGY | 2021年 / 58卷 / 05期

关键词：

COVID-19; Elderly; Mental health; Psychiatric disorders; Inflammation; CORONAVIRUS DISEASE 2019; OLDER-ADULTS; INFLAMMATORY RESPONSE; INFLUENZA VACCINATION; DEPRESSION; STRESS; IMMUNE; ACTIVATION; MECHANISMS; BIOMARKERS;

D O I：

10.1007/s12035-020-02249-x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Since December 2019, the world has been experiencing the challenge of facing coronavirus disease-19 (COVID-19), a severe infectious disease caused by the new coronavirus, SARS-CoV-2. The individuals with the most severe symptoms and the highest risk of death are the elderly and those with chronic illness. Among chronic conditions, those with a certain degree of chronic inflammation may predispose to a more severe evolution of COVID-19. Elderly with psychiatric disorders can present a persistent inflammatory state, a characteristic of the age's immunological senescence, but the disorder can accentuate that. Social isolation is still the safest way to avoid contamination. However, isolated older people may have or worsen mental health conditions due to isolation and health concerns. In this scenario, a SARS-CoV-2 infection may progress to more severe disease. Conversely, COVID-19 can predispose or aggravate psychiatric disorders, as it induces a cytokine storm, causing systemic hyper inflammation. It may damage the blood-brain barrier, resulting in inflammation in the central nervous system. Besides, SARS-CoV-2 is likely to reach and trigger an inflammatory process directly in the nervous system. This review makes an update about research on the mental health of the elderly during the pandemic. Also, it discusses the vulnerability of these individuals in the face of stress and in the case of contracting COVID-19, considering mainly the stress's hormonal and inflammatory mechanisms. Finally, the review points out possible care and attention strategies and entertainment and activities that can reduce the damage to mental and physical health and improve the elderly's quality of life. Graphical abstract Isolation and concerns about COVID-19 may harm elderly mental health. Immunosenescence and pandemic stress increase the risk of psychiatric disorders. Stress and disorders may potentiate the elderly's inflammation and COVID-19 symptoms. SARS-CoV-2 hyperinflammation is a risk factor for elderly psychiatric disorders

引用

页码：1905 / 1916

页数：12

共 95 条

[81] Coupling corticotropin-releasing-hormone and angiotensin converting enzyme 2 dampens stress responsiveness in male mice [J].