Conversion of peripheral CD4+CD25- T cells to CD4+CD25+ regulatory T cells by IFN-γ in patients with Guillain-Barre syndrome

被引：12

作者：

Huang, Shuo ^{[1
]}

Li, Lei ^{[1
]}

Liang, Songlan ^{[1
]}

Wang, Weizhi ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 2, Dept Neurol, Harbin 150086, Heilongjiang, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 217卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

Guillain-Barre syndrome (GBS); IFN-gamma; CD4(+)CD25(-) T cells; Induced CD4(+)CD25(+) regulatory; T cells (iTregs); CD4(+)CD25(+) regulatory T cells; (CD4(+)CD25(+) Tregs); PATHOGENESIS; TREGS; FOXP3; MICE;

D O I：

10.1016/j.jneuroim.2009.10.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD4(+)CD25(-) T cells from 25 Guillain-Barre syndrome (GBS) patients were stimulated by IFN-gamma to generate the induced CD4(+)CD25(+) regulatory T cells (iTregs). Then, their phenotypical and functional characterizations were analyzed. Results show that iTregs can be generated from CD4(+)CD25(-) T cells in GBS patients by IFN-gamma in the presence of activating anti-CD3 and anti-CD28 antibodies in vitro. When CD4(+)CD25(-) T cells are stimulated by 40 ng/ml IFN-gamma for 3 days, the ratio of conversion is the highest under this condition and iTregs are similar to naturally occurring CD4(+)CD25(+) regulatory T cells of healthy donors phenotypically and functionally. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：80 / 84

页数：5

共 25 条

[1] Anderson AE, 2008, ACTA REUMATOL PORT, V33, P17
[2] ASSESSMENT OF CURRENT DIAGNOSTIC-CRITERIA FOR GUILLAIN-BARRE-SYNDROME
ASBURY, AK
CORNBLATH, DR
[J]. ANNALS OF NEUROLOGY, 1990, 27 : S21 - S24
[3] CD4+CD25high regulatory cells in human peripheral blood
Baecher-Allan, C
Brown, JA
Freeman, GJ
Hafler, DA
[J]. JOURNAL OF IMMUNOLOGY, 2001, 167 (03) : 1245 - 1253
[4] Impairment of circulating CD4+CD25+ regulatory T cells in patients with chronic inflammatory demyelinating polyradiculoneuropathy
Chi, Li-Jun
Wang, Hua-Bing
Wang, Wei-Zhi
[J]. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2008, 13 (01) : 54 - 63
[5] Abnormality of circulating CD4+CD25+ regulatory T cell in patients with Guillain-Barre syndrome
Chi, Lijun
Wang, Hua-Bing
Zhang, Ying
Wang, Wei-Zhi
[J]. JOURNAL OF NEUROIMMUNOLOGY, 2007, 192 (1-2) : 206 - 214
[6] A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
Fontenot, JD
Rudensky, AY
[J]. NATURE IMMUNOLOGY, 2005, 6 (04) : 331 - 337
[7] Preceding infections, immune factors, and outcome in Guillain-Barre syndrome
Hadden, RDM
Karch, H
Hartung, HP
Zielasek, J
Weissbrich, B
Schubert, J
Weishaupt, A
Cornblath, DR
Swan, AV
Hughes, RAC
Toyka, KV
[J]. NEUROLOGY, 2001, 56 (06) : 758 - 765
[8] Control of regulatory T cell development by the transcription factor Foxp3
Hori, S
Nomura, T
Sakaguchi, S
[J]. SCIENCE, 2003, 299 (5609) : 1057 - 1061
[9] Pathogenesis of Guillain-Barre syndrome
Hughes, RAC
Hadden, RDM
Gregson, NA
Smith, KJ
[J]. JOURNAL OF NEUROIMMUNOLOGY, 1999, 100 (1-2) : 74 - 97
[10] Mechanisms of disease - Regulation of immune responses by T cells
Jiang, H
Chess, L
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (11) : 1166 - 1176

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