Diet-induced obesity obstructs insulin signaling in the heart

被引：4

作者：

Young, Lawrence H. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Sect Cardiovasc Med, Dept Internal Med, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Sect Cardiovasc Med, Dept Cellular & Mol Physiol, New Haven, CT 06520 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2010年 / 298卷 / 02期

关键词：

RECEPTOR SUBSTRATE-1; RESISTANCE; PHOSPHORYLATION; RISK; DYSFUNCTION; METABOLISM; MECHANISMS; EXPRESSION; SER(307); DISEASE;

D O I：

10.1152/ajpheart.01088.2009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：H306 / H307

页数：2

共 17 条

[1] Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action [J].

Aguirre, V ;

Werner, ED ;

Giraud, J ;

Lee, YH ;

Shoelson, SE ;

White, MF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (02) :1531-1537

[2] The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307 [J].

Aguirre, V ;

Uchida, T ;

Yenush, L ;

Davis, R ;

White, MF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (12) :9047-9054

[3] Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression [J].

Belke, DD ;

Betuing, S ;

Tuttle, MJ ;

Graveleau, C ;

Young, ME ;

Pham, M ;

Zhang, DF ;

Cooksey, RC ;

McClain, DA ;

Litwin, SE ;

Taegtmeyer, H ;

Severson, D ;

Kahn, CR ;

Abel, ED .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (05) :629-639

[4] Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity [J].

Boudina, S ;

Sena, S ;

O'Neill, BT ;

Tathireddy, P ;

Young, ME ;

Abel, ED .

CIRCULATION, 2005, 112 (17) :2686-2695

[5] Contribution of Impaired Myocardial Insulin Signaling to Mitochondrial Dysfunction and Oxidative Stress in the Heart [J].

Boudina, Sihem ;

Bugger, Heiko ;

Sena, Sandra ;

O'Neill, Brian T. ;

Zaha, Vlad G. ;

Ilkun, Olesya ;

Wright, Jordan J. ;

Mazumder, Pradip K. ;

Palfreyman, Eric ;

Tidwell, Timothy J. ;

Theobald, Heather ;

Khalimonchuk, Oleh ;

Wayment, Benjamin ;

Sheng, Xiaoming ;

Rodnick, Kenneth J. ;

Centini, Ryan ;

Chen, Dong ;

Litwin, Sheldon E. ;

Weimer, Bart E. ;

Abel, E. Dale .

CIRCULATION, 2009, 119 (09) :1272-U111

[6] Hyperinsulinemia as an independent risk factor for ischemic heart disease [J].

Despres, JP ;

Lamarche, B ;

Mauriege, P ;

Cantin, B ;

Dagenais, GR ;

Moorjani, S ;

Lupien, PJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (15) :952-957

[7] Prospective associations of fasting insulin, body fat distribution, and diabetes with risk of ischemic stroke [J].

Folsom, AR ;

Rasmussen, ML ;

Chambless, LE ;

Howard, G ;

Cooper, LS ;

Schmidt, MI ;

Heiss, G .

DIABETES CARE, 1999, 22 (07) :1077-1083

[8] Obesity and the risk of heart failure [J].

Kenchaiah, S ;

Evans, JC ;

Levy, D ;

Wilson, PWF ;

Benjamin, EJ ;

Larson, MG ;

Kannel, WB ;

Vasan, RS .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (05) :305-313

[9] Multiple abnormalities of myocardial insulin signaling in a porcine model of diet-induced obesity [J].

Lee, Jenny ;

Xu, Ya ;

Lu, Li ;

Bergman, Bryan ;

Leitner, J. Wayne ;

Greyson, Clifford ;

Draznin, Boris ;

Schwartz, Gregory G. .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2010, 298 (02) :H310-H319

[10]

Mauvais-Jarvis F, 2002, J CLIN INVEST, V109, P141, DOI 10.1172/JCI13305

← 1 2 →