Longitudinal Analysis of Genitourinary and Bowel Symptoms in Prostate Cancer Patients Following Brachytherapy

被引:5
作者
Eckman, Mark H. [1 ,2 ]
Ying, Jun [3 ]
Hertzfeld, Kara [4 ]
Kumar, Nitin [4 ]
Barrett, William [4 ]
机构
[1] Dept Med, Div Gen Internal Med, Cincinnati, OH USA
[2] Ctr Clin Effectiveness, Cincinnati, OH USA
[3] Univ Cincinnati, Dept Publ Hlth Sci, Cincinnati, OH 45267 USA
[4] Univ Cincinnati, Dept Radiat Oncol, Cincinnati, OH 45267 USA
来源
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 2010年 / 33卷 / 01期
关键词
brachytherapy; outcomes research; genotyping; shared decision making; QUALITY-OF-LIFE; SHARED DECISION-MAKING; EXTERNAL-BEAM RADIOTHERAPY; RADICAL PROSTATECTOMY; SEED IMPLANTATION; RADIATION; OUTCOMES; MEN; CARCINOMA; SURVIVAL;
D O I
10.1097/COC.0b013e31819cd364
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objectives: Multiple options with similar cure rates exist for men with localized adenocarcinoma of the prostate. Therefore, treatment-related morbidity is a major consideration for treatment selection. We present a descriptive, longitudinal analysis of genitourinary and bowel symptoms following treatment in a brachytherapy registry at the University of Cincinnati. Methods: Between 1995 and 2007, 394 consecutive patients with newly diagnosed early stage prostate cancer underwent radioactive I-125 seed implantation. Patients were followed for ail average of 5.0 +/- 3.1 years. Follow-up data regarding genitourinary and bowel symptoms and clinical/biochemical evidence of cancer recurrence were collected during posttreatment visits. Results: Forty percent of men developed urinary obstructive symptoms, generally within the first 3 to 6 months following brachytherapy. These symptoms resolved in a large proportion of men. Impaired potency occurred in 15% of men by 6 months and in more than 40% of men by 60 months. Bowel symptoms were less common and had a slower onset. Conclusion: Symptoms following brachytherapy each have their own temporal pattern for development and resolution. These patterns are well explained by the underlying pathophysiology of therapeutic radiation injury and healing. Men and their partners can use this information to guide and inform treatment decisions.
引用
收藏
页码:1 / 10
页数:10
相关论文
共 78 条
[1]   Plasma transforming growth factor β1 as a predictor of radiation pneumonitis [J].
Anscher, MS ;
Kong, FM ;
Andrews, K ;
Clough, R ;
Marks, LB ;
Bentel, G ;
Jirtle, RL .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1998, 41 (05) :1029-1035
[2]   A prospective analysis of tong-term quality of life after permanent I-125 brachytherapy for locatised prostate cancer [J].
Ash, Dan ;
Bottomley, David ;
Al-Qaisieh, Bashar ;
Carey, Brendan ;
Gould, Kath ;
Henry, Ann .
RADIOTHERAPY AND ONCOLOGY, 2007, 84 (02) :135-139
[3]   Case 15-2008: A 55-year-old man with an elevated prostate-specific antigen level and early-stage prostate cancer - Anatomical diagnosis - Adenocarcinoma of the prostate, Gleason score 6 of 10, clinical stage T1c [J].
Barry, Michael J. ;
Kaufman, Donald S. ;
Wu, Chin-Lee ;
Zietman, Anthony L. ;
McDougal, W. Scott ;
Young, Robert H. ;
Talcott, James A. ;
Dahl, Douglas M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (20) :2161-2168
[4]   Health decision aids to facilitate shared decision making in office practice [J].
Barry, MJ .
ANNALS OF INTERNAL MEDICINE, 2002, 136 (02) :127-135
[5]   CORRELATION OF THE AMERICAN-UROLOGICAL-ASSOCIATION SYMPTOM INDEX WITH SELF-ADMINISTERED VERSIONS OF THE MADSEN-IVERSEN, BOYARSKY AND MAINE MEDICAL ASSESSMENT PROGRAM SYMPTOM INDEXES [J].
BARRY, MJ ;
FOWLER, FJ ;
OLEARY, MP ;
BRUSKEWITZ, RC ;
HOLTGREWE, HL ;
MEBUST, WK ;
BLAIVAS, JG ;
COCKETT, ATK ;
WEIN, AJ .
JOURNAL OF UROLOGY, 1992, 148 (05) :1558-1563
[6]  
Barry MJ, 2001, CANCER-AM CANCER SOC, V91, P2302, DOI 10.1002/1097-0142(20010615)91:12<2302::AID-CNCR1262>3.0.CO
[7]  
2-P
[8]  
Barry MJ, 1992, J UROLOGY, V148, P1564
[9]   Side effects of permanent 1125 prostate seed implants in 667 patients treated in Leeds [J].
Bottomley, David ;
Ash, Dan ;
Al-Qaisieh, Bashar ;
Carey, Brendan ;
Joseph, Joji ;
St Clair, Shaun ;
Gould, Kathy .
RADIOTHERAPY AND ONCOLOGY, 2007, 82 (01) :46-49
[10]   Quality of life outcomes after brachytherapy for early stage prostate cancer [J].
Brandeis, JM ;
Litwin, MS ;
Burnison, CM ;
Reiter, RE .
JOURNAL OF UROLOGY, 2000, 163 (03) :851-857