Induction of mixed allogeneic chimerism for leukemia

被引：2

作者：

Seledtsov, VI ^{[1
]}

Seledtsova, GV ^{[1
]}

Avdeev, EV ^{[1
]}

Samarin, DM ^{[1
]}

Kozlov, VA ^{[1
]}

机构：

[1] INST CLIN IMMUNOL,DEPT EXPT IMMUNOL,NOVOSIBIRSK 630099,RUSSIA

来源：

LEUKEMIA RESEARCH | 1997年 / 21卷 / 10期

关键词：

graft-vs-leukemia effect; mixed allogeneic hematopoietic chimerism;

D O I：

10.1016/S0145-2126(97)00011-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hybrid (C56BL/6 x DBA) (BDF1; H-2(b)/H-2(d)) mice bearing the P815 leukemia (H-2(d)) were grafted with a (CBA x C57BL/6)F1 (CBF1; H-2(k)/H-2(b)) cell suspension, comprising bone marrow cells (BMC; 25 x 10(6)/mouse) and spleen cells (SC; 55 x 10(6)/mouse) on day -4, then treated with cyclophosphamide (200 mg/kg) on day -2 and finally grafted once more with CBF1 cells (25 x 10(6) BMC+7 x 10(6) SC) on day 0. Allogeneic cell graftings performed in this way induced durable mixed hematopoietic chimerism and significantly prolonged the survival of recipients, compared with that of leukemia-bearers grafted with syngeneic cells, The results obtained raise the possibility of using allogeneic hematopoietic tissue transplantation in combination with non-lethal cytoreductive therapy to induce a long-lasting graft-vs-leukemia effect. (C) 1997 Elsevier Science Ltd.

引用

页码：907 / 909

页数：3