Association of Vitamin D Pathway Genetic Variation and Thyroid Cancer

被引：19

作者：

Carvalho, Isabel S. ^{[1
]}

Goncalves, Catarina, I ^{[1
]}

Almeida, Joana T. ^{[1
]}

Azevedo, Teresa ^{[2
,3
]}

Martins, Teresa ^{[2
]}

Rodrigues, Fernando J. ^{[2
]}

Lemos, Manuel C. ^{[1
]}

机构：

[1] Univ Beira Interior, Hlth Sci Res Ctr, CICS UBI, P-6200506 Covilha, Portugal

[2] Inst Portugues Oncol Coimbra, Serv Endocrinol, P-3000075 Coimbra, Portugal

[3] Ctr Hosp Baixo Vouga, Serv Endocrinol, P-3810193 Aveiro, Portugal

来源：

GENES | 2019年 / 10卷 / 08期

关键词：

thyroid cancer; vitamin D; genetics; polymorphisms; D DEFICIENCY; RISK; CHOLESTEROL;

D O I：

10.3390/genes10080572

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Vitamin D is mostly known for its role in bone and calcium metabolism. However, studies have suggested that it also has inhibitory effects on tumor development and progression. Genetic variants close to genes that encode crucial enzymes for the synthesis (DHCR7 rs12785878), metabolism (CYP2R1 rs2060793) and degradation (CYP24A1 rs6013897) of vitamin D have been associated with serum levels of vitamin D. The aim of this case-control study was to determine the effect of these variants in the vitamin D pathway on the susceptibility to thyroid cancer. Five hundred patients with differentiated thyroid cancer and 500 controls were genotyped for the DHCR7 rs12785878, CYP2R1 rs2060793, and CYP24A1 rs6013897 variants. Genotype and allele frequencies were compared between patients and controls. The DHCR7 rs12785878 minor allele was associated with thyroid cancer under an additive (OR 1.38, 95% CI 1.15-1.65, p = 0.0004) and codominant (OR 1.88, 95% CI 1.30-2.74, p = 0.0021) model. These findings suggest that DHCR7 polymorphisms may be associated with an increased risk of thyroid cancer due to an effect of this gene on circulating vitamin D levels.

引用

页数：8

共 31 条

[1] Genome-wide association study of circulating vitamin D levels [J].

Ahn, Jiyoung ;

Yu, Kai ;

Stolzenberg-Solomon, Rachael ;

Simon, K. Claire ;

McCullough, Marjorie L. ;

Gallicchio, Lisa ;

Jacobs, Eric J. ;

Ascherio, Alberto ;

Helzlsouer, Kathy ;

Jacobs, Kevin B. ;

Li, Qizhai ;

Weinstein, Stephanie J. ;

Purdue, Mark ;

Virtamo, Jarmo ;

Horst, Ronald ;

Wheeler, William ;

Chanock, Stephen ;

Hunter, David J. ;

Hayes, Richard B. ;

Kraft, Peter ;

Albanes, Demetrius .

HUMAN MOLECULAR GENETICS, 2010, 19 (13) :2739-2745

[2] An exploratory analysis of common genetic variants in the vitamin D pathway including genome-wide associated variants in relation to glioma risk and outcome [J].

Anic, Gabriella M. ;

Thompson, Reid C. ;

Nabors, L. Burton ;

Olson, Jeffrey J. ;

Browning, James E. ;

Madden, Melissa H. ;

Murtagh, F. Reed ;

Forsyth, Peter A. ;

Egan, Kathleen M. .

CANCER CAUSES & CONTROL, 2012, 23 (09) :1443-1449

[3] Genetic and epigenetic factors influencing vitamin D status [J].

Bahrami, Afsane ;

Sadeghnia, Hamid Reza ;

Tabatabaeizadeh, Seyed-Amir ;

Bahrami-Taghanaki, Hamidreza ;

Behboodi, Negin ;

Esmaeili, Habibollah ;

Ferns, Gordon A. ;

Mobarhan, Majid Ghayour ;

Avan, Amir .

JOURNAL OF CELLULAR PHYSIOLOGY, 2018, 233 (05) :4033-4043

[4] Genetic and Racial Differences in the Vitamin D Endocrine System [J].

Bouillon, Roger .

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2017, 46 (04) :1119-+

[5] Vitamin D Receptor Signaling and Cancer [J].

Campbell, Moray J. ;

Trump, Donald L. .

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2017, 46 (04) :1009-1038

[6] Vitamin D in thyroid tumorigenesis and development [J].

Clinckspoor, Isabelle ;

Verlinden, Lieve ;

Mathieu, Chantal ;

Bouillon, Roger ;

Verstuyf, Annemieke ;

Decallonne, Brigitte .

PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY, 2013, 48 (02) :65-98

[7] Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study [J].

Dimitrakopoulou, Vasiliki I. ;

Tsilidis, Konstantinos K. ;

Haycock, Philip C. ;

Dimou, Niki L. ;

Al-Dabhani, Kawthar ;

Martin, Richard M. ;

Lewis, Sarah J. ;

Gunter, Marc J. ;

Mondul, Alison ;

Shui, Irene M. ;

Theodoratou, Evropi ;

Nimptsch, Katharina ;

Lindstrom, Sara ;

Albanes, Demetrius ;

Kuehn, Tilman ;

Key, Timothy J. ;

Travis, Ruth C. ;

Vimaleswaran, Karani Santhanakrishnan ;

Kraft, Peter ;

Pierce, Brandon L. ;

Schildkraut, Joellen M. .

BMJ-BRITISH MEDICAL JOURNAL, 2017, 359 :j4761

[8] Power and sample size calculations for studies involving linear regression [J].

Dupont, WD ;

Plummer, WD .

CONTROLLED CLINICAL TRIALS, 1998, 19 (06) :589-601

[9] Vitamin D Insufficiency in Arabs and South Asians Positively Associates with Polymorphisms in GC and CYP2R1 Genes [J].

Elkum, Naser ;

Alkayal, Fadi ;

Noronha, Fiona ;

Ali, Maisa M. ;

Melhem, Motasem ;

Al-Arouj, Monira ;

Bennakhi, Abdullah ;

Behbehani, Kazem ;

Alsmadi, Osama ;

Abubaker, Jehad .

PLOS ONE, 2014, 9 (11)

[10] Genetic Predictors of Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer [J].

Hiraki, Linda T. ;

Qu, Conghui ;

Hutter, Carolyn M. ;

Baron, John A. ;

Berndt, Sonja I. ;

Bezieau, Stephane ;

Brenner, Hermann ;

Caan, Bette J. ;

Casey, Graham ;

Chang-Claude, Jenny ;

Chanock, Stephen J. ;

Conti, David V. ;

Duggan, David ;

Fuchs, Charles S. ;

Gallinger, Steven ;

Giovannucci, Edward L. ;

Harrison, Tabitha A. ;

Hayes, Richard B. ;

Hazra, Aditi ;

Henderson, Brian ;

Hoffmeister, Michael ;

Hopper, John L. ;

Hudson, Thomas J. ;

Jenkins, Mark A. ;

Kuery, S. Ebastien ;

Le Marchand, Loic ;

Lemire, Mathieu ;

Ma, Jing ;

Manson, JoAnn E. ;

Nan, Hongmei ;

Newcomb, Polly A. ;

Ng, Kimmie ;

Potter, John D. ;

Schoen, Robert E. ;

Schumacher, Fredrick R. ;

Seminara, Daniela ;

Slattery, Martha L. ;

Wactawski-Wende, Jean ;

White, Emily ;

Wu, Kana ;

Zanke, Brent W. ;

Kraft, Peter ;

Peters, Ulrike ;

Chan, Andrew T. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2013, 22 (11) :2037-2046

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