An Efficient and Direct Synthesis of 2-Thiopyridines via Microwave-Assisted Three-Component Reaction

被引：4

作者：

Wang, Xing-Han ^{[1
]}

Cao, Xu-Dong ^{[1
]}

Tu, Shu-Jiang ^{[1
]}

Zhang, Xiao-Hong ^{[1
]}

Hao, Wen-Juan ^{[1
]}

Yan, Shu ^{[1
]}

Wu, Shan-Shan ^{[1
]}

Han, Zheng-Guo ^{[1
]}

Shi, Feng ^{[1
]}

机构：

[1] Xuzhou Normal Univ, Sch Chem & Chem Engn, Key Lab Biotechnol Med Plant, Xuzhou 221116, Jiangsu, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 46卷 / 05期

基金：

美国国家科学基金会;

关键词：

MULTICOMPONENT REACTION; ONE-STEP; DERIVATIVES;

D O I：

10.1002/jhet.161

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 2-p-tolylthiopyridine derivatives was directly synthesized via three-component reactions of chalcones, malononitrile, and 4-methylbenzenethiol catalyzed by Et3N in DMF under microwave irradiation. It is an efficient and promising synthetic strategy to construct 2-thiopyridine skeleton with the advantage of short time, excellent yield, and convenient operation.

引用

页码：886 / 889

页数：4

共 17 条

[1]

AIVARS K, 1999, EUR J MED CHEM, V34, P301

[2]

[Anonymous], 1975, PYRIDINE ITS DERI S4

[3] A novel three-component one-pot synthesis of pyrano[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines using microwave heating in the solid state [J].