Consistency checks to improve measurement with the Montgomery-Asberg Depression Rating Scale (MADRS)

被引：8

作者：

Rabinowitz, Jonathan ^{[1
]}

Schooler, Nina R. ^{[2
]}

Brown, Brianne ^{[3
]}

Dalsgaard, Mads ^{[4
]}

Engelhardt, Nina ^{[5
]}

Friedberger, Gretchen ^{[6
]}

Kinon, Bruce J. ^{[7
]}

Lee, Daniel ^{[8
]}

Ockun, Felice ^{[9
]}

Mahableshwarkar, Atul ^{[10
]}

Tsai, Joyce ^{[11
]}

Williams, Janet B. W. ^{[12
]}

Sauder, Colin ^{[13
,14
]}

Yavorsky, Christian ^{[15
]}

Ariana

Elizbeth

Chris

Brianne

Juliet

Joan

Kimberly

David

Michael

Bernadette

Walter

Amy

Nina

Hans

Dong-Jing

Sharon

Paul

Ivan

Nanco

Christina

Amir

John

Anzalee

Alan

Daniel

Jennifer

Victor

Atul

Jennifer

Francois

Kari

Selam

Ramzey

Mark

Jonathan

Thomas

机构：

[1] Bar Ilan Univ, Ramat Gan, Israel

[2] SUNY Downstate Med Ctr, 450 Clarkson Ave,MSC 1203, Brooklyn, NY 11203 USA

[3] Janssen Sci Affairs LLC, 1125 Trenton Harbourton Rd, Titusville, NJ 08560 USA

[4] Lundbeck AS, Ottiliavej 9, DK-2500 Valby, Denmark

[5] Intracellular Therapies, 430 East 29th St,Suite 900, New York, NY 10016 USA

[6] Bracket Global LLC, POB 7137, Mclean, VA 22106 USA

[7] Lundbeck North Amer, 6 Pkwy North,Suite 400, Deerfield, IL 60015 USA

[8] US FDA, Div Psychiat Prod, 10903 New Hampshire Ave, Silver Spring, MD 20993 USA

[9] Medavante ProPhase LLC, 3 Pk Ave, New York, NY 10016 USA

[10] BlackThorn Therapeut Inc, 780 Brannan St, San Francisco, CA USA

[11] Sunov Pharmaceut, One Bridge Plaza North,Suite 510, Ft Lee, NJ 07024 USA

[12] Columbia Univ, Dept Psychiat, 2466 Westlake Ave N,19, Seattle, WA 98109 USA

[13] Adams Clin, 521 Mt Auburn St,Suite 107, Watertown, MA 02472 USA

[14] UT Hlth San Antonio, Dept Psychiat, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA

[15] Cronos CCS, 201 South Main St, Lambertville, NJ 08530 USA

来源：

JOURNAL OF AFFECTIVE DISORDERS | 2019年 / 256卷

基金：

芬兰科学院;

关键词：

D O I：

10.1016/j.jad.2019.05.077

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

International Society for CNS Clinical Trials and Methodology convened an expert Working Group that assembled consistency/inconsistency flags for the Montgomery-Asberg Depression Rating Scale (MADRS). Twenty-two flags were identified. Seven flags are believed to be strong flags that suggest that a thorough review of rating is warranted. The flags were applied to assessments derived from the NEWMEDS data repository. Almost 65% of ratings had at least one inconsistency flag raised and 22% had two or more. Application of flags to clinical ratings may improve reliability of ratings and validity of trials.

引用

页码：143 / 147

页数：5

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